Chromosome 20q Amplification Regulates in Vitro Response to Kinesin-5 Inhibitor

We identified gene expression signatures predicting responsiveness to a Kinesin-5 (KIF11) inhibitor (Kinesin-5i) in cultured colon tumor cell lines. Genes predicting resistance to Kinesin-5i were enriched for those from chromosome 20q, a region of frequent amplification in a number of tumor types. s...

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Detalles Bibliográficos
Autores principales: Jackson, Aimee L., Mao, Mao, Kobayashi, Sumire, Ward, Teresa, Biery, Matthew, Dai, Hongyue, Bartz, Steven R., Linsley, Peter S.
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2008
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621078/
https://www.ncbi.nlm.nih.gov/pubmed/19259408

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