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Genetic Variation on Chromosome 6 Influences F Cell Levels in Healthy Individuals of African Descent and HbF Levels in Sickle Cell Patients

Fetal haemoglobin (HbF) is a major ameliorating factor in sickle cell disease. We investigated if a quantitative trait locus on chromosome 6q23 was significantly associated with HbF and F cell levels in individuals of African descent. Single nucleotide polymorphisms (SNPs) in a 24-kb intergenic regi...

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Detalles Bibliográficos
Autores principales:	Creary, Lisa E., Ulug, Pinar, Menzel, Stephan, McKenzie, Colin A., Hanchard, Neil A., Taylor, Veronica, Farrall, Martin, Forrester, Terrence E., Thein, Swee Lay
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621086/ https://www.ncbi.nlm.nih.gov/pubmed/19148297 http://dx.doi.org/10.1371/journal.pone.0004218

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