Cargando…

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

Chromosome structural changes with nonrecurrent endpoints associated with genomic disorders offer windows into the mechanism of origin of copy number variation (CNV). A recent report of nonrecurrent duplications associated with Pelizaeus-Merzbacher disease identified three distinctive characteristic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hastings, P. J., Ira, Grzegorz, Lupski, James R.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621351/ https://www.ncbi.nlm.nih.gov/pubmed/19180184 http://dx.doi.org/10.1371/journal.pgen.1000327

Ejemplares similares

RPA Antagonizes Microhomology-Mediated Repair of DNA Double-Strand Breaks
por: Deng, Sarah K, et al.
Publicado: (2014)

Microhomology Selection for Microhomology Mediated End Joining in Saccharomyces cerevisiae
por: Lee, Kihoon, et al.
Publicado: (2019)

A case with concurrent duplication, triplication, and uniparental isodisomy at 1q42.12-qter supporting microhomology-mediated break-induced replication model for replicative rearrangements
por: Kohmoto, Tomohiro, et al.
Publicado: (2017)

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations
por: Villarreal, Diana D., et al.
Publicado: (2012)

Plant organellar DNA polymerases repair double-stranded breaks by microhomology-mediated end-joining
por: García-Medel, Paola L, et al.
Publicado: (2019)

Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
por: Tadi, Satish Kumar, et al.
Publicado: (2016)

Novel origins of copy number variation in the dog genome
por: Berglund, Jonas, et al.
Publicado: (2012)

The impact and origin of copy number variations in the Oryza species
por: Bai, Zetao, et al.
Publicado: (2016)

Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
por: Liang, Li, et al.
Publicado: (2008)

Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes
por: Glover, Lucy, et al.
Publicado: (2008)

Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
por: Sinha, Supriya, et al.
Publicado: (2017)

Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress
por: Jiang, Yuning
Publicado: (2022)

Genome-wide estimation of firing efficiencies of origins of DNA replication from time-course copy number variation data
por: Luo, Huaien, et al.
Publicado: (2010)

Microhomology-mediated deletion and gene conversion in African trypanosomes
por: Glover, Lucy, et al.
Publicado: (2011)

Microhomology-Mediated Intron Loss during Metazoan Evolution
por: van Schendel, Robin, et al.
Publicado: (2013)

Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the FOXL2 Gene or Its Regulatory Domain
por: Verdin, Hannah, et al.
Publicado: (2013)

Assays for DNA double-strand break repair by microhomology-based end-joining repair mechanisms
por: Kostyrko, Kaja, et al.
Publicado: (2016)

Origins and Long-Term Patterns of Copy-Number Variation in Rhesus Macaques
por: Thomas, Gregg W C, et al.
Publicado: (2020)

Microhomologies Are Associated with Tandem Duplications and Structural Variation in Plant Mitochondrial Genomes
por: Xia, Hanhan, et al.
Publicado: (2020)

Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta
por: Kent, Tatiana, et al.
Publicado: (2015)

Copy number analysis of the low-copy repeats at the primate NPHP1 locus by array comparative genomic hybridization
por: Yuan, Bo, et al.
Publicado: (2016)

Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining
por: Singer, Mirko, et al.
Publicado: (2015)

Microhomology-mediated end joining: new players join the team
por: Wang, Hailong, et al.
Publicado: (2017)

Distribution, functional impact, and origin mechanisms of copy number variation in the barley genome
por: Muñoz-Amatriaín, María, et al.
Publicado: (2013)

Copy number variations and cancer
por: Shlien, Adam, et al.
Publicado: (2009)

Copy number variations and stroke
por: Colaianni, Valeria, et al.
Publicado: (2016)

Copy Number Variations and Schizophrenia
por: Szecówka, Kamila, et al.
Publicado: (2022)

Copy Number Variation and Osteoporosis
por: Lovšin, Nika
Publicado: (2023)

A role for human homologous recombination factors in suppressing microhomology-mediated end joining
por: Ahrabi, Sara, et al.
Publicado: (2016)

Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization
por: Marioni, John C, et al.
Publicado: (2007)

Copy number variation signature to predict human ancestry
por: Pronold, Melissa, et al.
Publicado: (2012)

Large multi-allelic copy number variations in humans
por: Handsaker, Robert E., et al.
Publicado: (2015)

Copy-number-variation and copy-number-alteration region detection by cumulative plots
por: Li, Wentian, et al.
Publicado: (2009)

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining
por: Feldman, Tzah, et al.
Publicado: (2021)

Analysis of copy number variations and possible candidate genes in spontaneous abortion by copy number variation sequencing
por: Bai, Wei, et al.
Publicado: (2023)

Microhomology-assisted scarless genome editing in human iPSCs
por: Kim, Shin-Il, et al.
Publicado: (2018)

Microhomologies are prevalent at Cas9-induced larger deletions
por: Owens, Dominic D G, et al.
Publicado: (2019)

Multiple de novo copy number variations in two subjects with developmental problems and multiple congenital anomalies
por: Liu, Pengfei, et al.
Publicado: (2012)

Copy number variation in African Americans
por: McElroy, Joseph P, et al.
Publicado: (2009)

Copy number variation goes clinical
por: Le Caignec, Cédric, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_g0gfpvd1hr8dc3m9v8tbrrkg30