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Optimizing prophylactic treatment of migraine: Subtypes and patient matching
Advances in our understanding of the pathophysiology of migraine have resulted in important breakthroughs in treatment. For example, understanding of the role of serotonin in the cerebrovascular circulation has led to the development of triptans for the acute relief of migraine headaches, and the id...
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621398/ https://www.ncbi.nlm.nih.gov/pubmed/19209286 |
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author | Dib, Michel |
author_facet | Dib, Michel |
author_sort | Dib, Michel |
collection | PubMed |
description | Advances in our understanding of the pathophysiology of migraine have resulted in important breakthroughs in treatment. For example, understanding of the role of serotonin in the cerebrovascular circulation has led to the development of triptans for the acute relief of migraine headaches, and the identification of cortical spreading depression as an early central event associated wih migraine has brought renewed interest in antiepileptic drugs for migraine prophylaxis. However, migraine still remains inadequately treated. Indeed, it is apparent that migraine is not a single disease but rather a syndrome that can manifest itself in a variety of pathological conditions. The consequences of this may be that treatment needs to be matched to particular patients. Clinical research needs to be devoted to identifying which sort of patients benefit best from which treatments, particularly in the field of prophylaxis. We propose four patterns of precipitating factors (adrenergic, serotoninergic, menstrual, and muscular) which may be used to structure migraine prophylaxis. Finally, little is known about long-term outcome in treated migraine. It is possible that appropriate early prophylaxis may modify the long-term course of the disease and avoid late complications. |
format | Text |
id | pubmed-2621398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-26213982009-02-10 Optimizing prophylactic treatment of migraine: Subtypes and patient matching Dib, Michel Ther Clin Risk Manag Review Advances in our understanding of the pathophysiology of migraine have resulted in important breakthroughs in treatment. For example, understanding of the role of serotonin in the cerebrovascular circulation has led to the development of triptans for the acute relief of migraine headaches, and the identification of cortical spreading depression as an early central event associated wih migraine has brought renewed interest in antiepileptic drugs for migraine prophylaxis. However, migraine still remains inadequately treated. Indeed, it is apparent that migraine is not a single disease but rather a syndrome that can manifest itself in a variety of pathological conditions. The consequences of this may be that treatment needs to be matched to particular patients. Clinical research needs to be devoted to identifying which sort of patients benefit best from which treatments, particularly in the field of prophylaxis. We propose four patterns of precipitating factors (adrenergic, serotoninergic, menstrual, and muscular) which may be used to structure migraine prophylaxis. Finally, little is known about long-term outcome in treated migraine. It is possible that appropriate early prophylaxis may modify the long-term course of the disease and avoid late complications. Dove Medical Press 2008-10 2008-10 /pmc/articles/PMC2621398/ /pubmed/19209286 Text en © 2008 Dove Medical Press Limited. All rights reserved |
spellingShingle | Review Dib, Michel Optimizing prophylactic treatment of migraine: Subtypes and patient matching |
title | Optimizing prophylactic treatment of migraine: Subtypes and patient matching |
title_full | Optimizing prophylactic treatment of migraine: Subtypes and patient matching |
title_fullStr | Optimizing prophylactic treatment of migraine: Subtypes and patient matching |
title_full_unstemmed | Optimizing prophylactic treatment of migraine: Subtypes and patient matching |
title_short | Optimizing prophylactic treatment of migraine: Subtypes and patient matching |
title_sort | optimizing prophylactic treatment of migraine: subtypes and patient matching |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621398/ https://www.ncbi.nlm.nih.gov/pubmed/19209286 |
work_keys_str_mv | AT dibmichel optimizingprophylactictreatmentofmigrainesubtypesandpatientmatching |