Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides

Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10–60 mg...

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Detalles Bibliográficos
Autores principales: Breneman, Debra L, Storer, Timothy J, Breneman, John C, Mutasim, Diya F
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621414/
https://www.ncbi.nlm.nih.gov/pubmed/19209294
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author Breneman, Debra L
Storer, Timothy J
Breneman, John C
Mutasim, Diya F
author_facet Breneman, Debra L
Storer, Timothy J
Breneman, John C
Mutasim, Diya F
author_sort Breneman, Debra L
collection PubMed
description Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10–60 mg. All 4 patients were erythrodermic, which may have predisposed them to this toxic effect. It is important to recognize cutaneous ulceration as an uncommon, but potentially serious, side effect of methotrexate in these patients, and to differentiate it from ulceration due to progressive lymphoma.
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spelling pubmed-26214142009-02-10 Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides Breneman, Debra L Storer, Timothy J Breneman, John C Mutasim, Diya F Ther Clin Risk Manag Case Study Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10–60 mg. All 4 patients were erythrodermic, which may have predisposed them to this toxic effect. It is important to recognize cutaneous ulceration as an uncommon, but potentially serious, side effect of methotrexate in these patients, and to differentiate it from ulceration due to progressive lymphoma. Dove Medical Press 2008-10 2008-10 /pmc/articles/PMC2621414/ /pubmed/19209294 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Case Study
Breneman, Debra L
Storer, Timothy J
Breneman, John C
Mutasim, Diya F
Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
title Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
title_full Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
title_fullStr Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
title_full_unstemmed Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
title_short Methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
title_sort methotrexate-induced cutaneous ulceration in patients with erythrodermic mycosis fungoides
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621414/
https://www.ncbi.nlm.nih.gov/pubmed/19209294
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AT storertimothyj methotrexateinducedcutaneousulcerationinpatientswitherythrodermicmycosisfungoides
AT brenemanjohnc methotrexateinducedcutaneousulcerationinpatientswitherythrodermicmycosisfungoides
AT mutasimdiyaf methotrexateinducedcutaneousulcerationinpatientswitherythrodermicmycosisfungoides

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