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Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice

BACKGROUND: It is generally recognized that recurrent aggression can be the result of various psychiatric disorders. The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly be associated with aggression consistently sho...

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Autores principales: Bondar, Natalia P., Boyarskikh, Ul'yana A., Kovalenko, Irina L., Filipenko, Maxim L., Kudryavtseva, Natalia N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622718/
https://www.ncbi.nlm.nih.gov/pubmed/19142237
http://dx.doi.org/10.1371/journal.pone.0004190
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author Bondar, Natalia P.
Boyarskikh, Ul'yana A.
Kovalenko, Irina L.
Filipenko, Maxim L.
Kudryavtseva, Natalia N.
author_facet Bondar, Natalia P.
Boyarskikh, Ul'yana A.
Kovalenko, Irina L.
Filipenko, Maxim L.
Kudryavtseva, Natalia N.
author_sort Bondar, Natalia P.
collection PubMed
description BACKGROUND: It is generally recognized that recurrent aggression can be the result of various psychiatric disorders. The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly be associated with aggression consistently shown by male mice in special experimental settings. METHODOLOGY/PRINCIPAL FINDINGS: The genes were Th, Dat1, Snca and Bdnf; the male mice were a group of animals that had each won 20 daily encounters in succession and a group of animals that had the same winning track record followed by a no-fight period for 14 days. Increased Th, Dat1 and Snca mRNA levels were in the fresh-from-the-fight group as compared to the controls. Increased Th and Dat1 mRNA levels were in the no-fight winners as compared to the controls. Significant positive correlations were found between the level of aggression and Th and Snca mRNA levels. CONCLUSIONS: Repeated positive fighting experience enhances the expression of the Th, Dat1 and Snca genes, which are associated with brain dopaminergic systems. The expression of the Th and Dat1 genes stays enhanced for a long time.
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spelling pubmed-26227182009-01-14 Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice Bondar, Natalia P. Boyarskikh, Ul'yana A. Kovalenko, Irina L. Filipenko, Maxim L. Kudryavtseva, Natalia N. PLoS One Research Article BACKGROUND: It is generally recognized that recurrent aggression can be the result of various psychiatric disorders. The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly be associated with aggression consistently shown by male mice in special experimental settings. METHODOLOGY/PRINCIPAL FINDINGS: The genes were Th, Dat1, Snca and Bdnf; the male mice were a group of animals that had each won 20 daily encounters in succession and a group of animals that had the same winning track record followed by a no-fight period for 14 days. Increased Th, Dat1 and Snca mRNA levels were in the fresh-from-the-fight group as compared to the controls. Increased Th and Dat1 mRNA levels were in the no-fight winners as compared to the controls. Significant positive correlations were found between the level of aggression and Th and Snca mRNA levels. CONCLUSIONS: Repeated positive fighting experience enhances the expression of the Th, Dat1 and Snca genes, which are associated with brain dopaminergic systems. The expression of the Th and Dat1 genes stays enhanced for a long time. Public Library of Science 2009-01-14 /pmc/articles/PMC2622718/ /pubmed/19142237 http://dx.doi.org/10.1371/journal.pone.0004190 Text en Bondar et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Bondar, Natalia P.
Boyarskikh, Ul'yana A.
Kovalenko, Irina L.
Filipenko, Maxim L.
Kudryavtseva, Natalia N.
Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
title Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
title_full Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
title_fullStr Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
title_full_unstemmed Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
title_short Molecular Implications of Repeated Aggression: Th, Dat1, Snca and Bdnf Gene Expression in the VTA of Victorious Male Mice
title_sort molecular implications of repeated aggression: th, dat1, snca and bdnf gene expression in the vta of victorious male mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2622718/
https://www.ncbi.nlm.nih.gov/pubmed/19142237
http://dx.doi.org/10.1371/journal.pone.0004190
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