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Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain

BACKGROUND: The Contact Heat Evoked Potential Stimulator (CHEPS) utilises rapidly delivered heat pulses with adjustable peak temperatures to stimulate the differential warm/heat thresholds of receptors expressed by Aδ and C fibres. The resulting evoked potentials can be recorded and measured, provid...

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Autores principales: Roberts, Katherine, Papadaki, Anastasia, Gonçalves, Carla, Tighe, Mary, Atherton, Duncan, Shenoy, Ravikiran, McRobbie, Donald, Anand, Praveen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625333/
https://www.ncbi.nlm.nih.gov/pubmed/19091117
http://dx.doi.org/10.1186/1471-2253-8-8
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author Roberts, Katherine
Papadaki, Anastasia
Gonçalves, Carla
Tighe, Mary
Atherton, Duncan
Shenoy, Ravikiran
McRobbie, Donald
Anand, Praveen
author_facet Roberts, Katherine
Papadaki, Anastasia
Gonçalves, Carla
Tighe, Mary
Atherton, Duncan
Shenoy, Ravikiran
McRobbie, Donald
Anand, Praveen
author_sort Roberts, Katherine
collection PubMed
description BACKGROUND: The Contact Heat Evoked Potential Stimulator (CHEPS) utilises rapidly delivered heat pulses with adjustable peak temperatures to stimulate the differential warm/heat thresholds of receptors expressed by Aδ and C fibres. The resulting evoked potentials can be recorded and measured, providing a useful clinical tool for the study of thermal and nociceptive pathways. Concurrent recording of contact heat evoked potentials using electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has not previously been reported with CHEPS. Developing simultaneous EEG and fMRI with CHEPS is highly desirable, as it provides an opportunity to exploit the high temporal resolution of EEG and the high spatial resolution of fMRI to study the reaction of the human brain to thermal and nociceptive stimuli. METHODS: In this study we have recorded evoked potentials stimulated by 51°C contact heat pulses from CHEPS using EEG, under normal conditions (baseline), and during continuous and simultaneous acquisition of fMRI images in ten healthy volunteers, during two sessions. The pain evoked by CHEPS was recorded on a Visual Analogue Scale (VAS). RESULTS: Analysis of EEG data revealed that the latencies and amplitudes of evoked potentials recorded during continuous fMRI did not differ significantly from baseline recordings. fMRI results were consistent with previous thermal pain studies, and showed Blood Oxygen Level Dependent (BOLD) changes in the insula, post-central gyrus, supplementary motor area (SMA), middle cingulate cortex and pre-central gyrus. There was a significant positive correlation between the evoked potential amplitude (EEG) and the psychophysical perception of pain on the VAS. CONCLUSION: The results of this study demonstrate the feasibility of recording contact heat evoked potentials with EEG during continuous and simultaneous fMRI. The combined use of the two methods can lead to identification of distinct patterns of brain activity indicative of pain and pro-nociceptive sensitisation in healthy subjects and chronic pain patients. Further studies are required for the technique to progress as a useful tool in clinical trials of novel analgesics.
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spelling pubmed-26253332009-01-14 Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain Roberts, Katherine Papadaki, Anastasia Gonçalves, Carla Tighe, Mary Atherton, Duncan Shenoy, Ravikiran McRobbie, Donald Anand, Praveen BMC Anesthesiol Technical Advance BACKGROUND: The Contact Heat Evoked Potential Stimulator (CHEPS) utilises rapidly delivered heat pulses with adjustable peak temperatures to stimulate the differential warm/heat thresholds of receptors expressed by Aδ and C fibres. The resulting evoked potentials can be recorded and measured, providing a useful clinical tool for the study of thermal and nociceptive pathways. Concurrent recording of contact heat evoked potentials using electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has not previously been reported with CHEPS. Developing simultaneous EEG and fMRI with CHEPS is highly desirable, as it provides an opportunity to exploit the high temporal resolution of EEG and the high spatial resolution of fMRI to study the reaction of the human brain to thermal and nociceptive stimuli. METHODS: In this study we have recorded evoked potentials stimulated by 51°C contact heat pulses from CHEPS using EEG, under normal conditions (baseline), and during continuous and simultaneous acquisition of fMRI images in ten healthy volunteers, during two sessions. The pain evoked by CHEPS was recorded on a Visual Analogue Scale (VAS). RESULTS: Analysis of EEG data revealed that the latencies and amplitudes of evoked potentials recorded during continuous fMRI did not differ significantly from baseline recordings. fMRI results were consistent with previous thermal pain studies, and showed Blood Oxygen Level Dependent (BOLD) changes in the insula, post-central gyrus, supplementary motor area (SMA), middle cingulate cortex and pre-central gyrus. There was a significant positive correlation between the evoked potential amplitude (EEG) and the psychophysical perception of pain on the VAS. CONCLUSION: The results of this study demonstrate the feasibility of recording contact heat evoked potentials with EEG during continuous and simultaneous fMRI. The combined use of the two methods can lead to identification of distinct patterns of brain activity indicative of pain and pro-nociceptive sensitisation in healthy subjects and chronic pain patients. Further studies are required for the technique to progress as a useful tool in clinical trials of novel analgesics. BioMed Central 2008-12-17 /pmc/articles/PMC2625333/ /pubmed/19091117 http://dx.doi.org/10.1186/1471-2253-8-8 Text en Copyright © 2008 Roberts et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technical Advance
Roberts, Katherine
Papadaki, Anastasia
Gonçalves, Carla
Tighe, Mary
Atherton, Duncan
Shenoy, Ravikiran
McRobbie, Donald
Anand, Praveen
Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
title Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
title_full Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
title_fullStr Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
title_full_unstemmed Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
title_short Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain
title_sort contact heat evoked potentials using simultaneous eeg and fmri and their correlation with evoked pain
topic Technical Advance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625333/
https://www.ncbi.nlm.nih.gov/pubmed/19091117
http://dx.doi.org/10.1186/1471-2253-8-8
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