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Effect of Testosterone on Insulin Stimulated IRS1 Ser Phosphorylation in Primary Rat Myotubes—A Potential Model for PCOS-Related Insulin Resistance

BACKGROUND: Polycystic ovary syndrome (PCOS) is characterized by a hyperandrogenic state and frequently develops skeletal muscle insulin resistance. We determined whether testosterone adversely affects insulin action by increasing serine phosphorylation of IRS-1(636/639) in differentiated rat skelet...

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Detalles Bibliográficos
Autores principales:	Allemand, Michael C., Irving, Brian A., Asmann, Yan W., Klaus, Katherine A., Tatpati, Laura, Coddington, Charles C., Nair, K. Sreekumaran
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2625432/ https://www.ncbi.nlm.nih.gov/pubmed/19169352 http://dx.doi.org/10.1371/journal.pone.0004274

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