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Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF

BACKGROUND: To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa. MurF catalyzes the formation of a peptide bond between D-Alanyl-D-Alanine (D-Ala-D-Ala...

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Detalles Bibliográficos
Autores principales:	Paradis-Bleau, Catherine, Lloyd, Adrian, Sanschagrin, François, Clarke, Tom, Blewett, Ann, Bugg, Timothy DH, Levesque, Roger C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626591/ https://www.ncbi.nlm.nih.gov/pubmed/19099588 http://dx.doi.org/10.1186/1471-2091-9-33

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