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The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression
BACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series o...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626627/ https://www.ncbi.nlm.nih.gov/pubmed/19156213 http://dx.doi.org/10.1371/journal.pone.0004223 |
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author | Dupouy, Sandra Viardot-Foucault, Véronique Alifano, Marco Souazé, Frédérique Plu-Bureau, Geneviève Chaouat, Marc Lavaur, Anne Hugol, Danielle Gespach, Christian Gompel, Anne Forgez, Patricia |
author_facet | Dupouy, Sandra Viardot-Foucault, Véronique Alifano, Marco Souazé, Frédérique Plu-Bureau, Geneviève Chaouat, Marc Lavaur, Anne Hugol, Danielle Gespach, Christian Gompel, Anne Forgez, Patricia |
author_sort | Dupouy, Sandra |
collection | PubMed |
description | BACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion. METHODS AND RESULTS: we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients. CONCLUSION: these data support the activation of neurotensinergic deleterious pathways in breast cancer progression. |
format | Text |
id | pubmed-2626627 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26266272009-01-19 The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression Dupouy, Sandra Viardot-Foucault, Véronique Alifano, Marco Souazé, Frédérique Plu-Bureau, Geneviève Chaouat, Marc Lavaur, Anne Hugol, Danielle Gespach, Christian Gompel, Anne Forgez, Patricia PLoS One Research Article BACKGROUND: The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion. METHODS AND RESULTS: we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients. CONCLUSION: these data support the activation of neurotensinergic deleterious pathways in breast cancer progression. Public Library of Science 2009-01-19 /pmc/articles/PMC2626627/ /pubmed/19156213 http://dx.doi.org/10.1371/journal.pone.0004223 Text en Dupouy et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Dupouy, Sandra Viardot-Foucault, Véronique Alifano, Marco Souazé, Frédérique Plu-Bureau, Geneviève Chaouat, Marc Lavaur, Anne Hugol, Danielle Gespach, Christian Gompel, Anne Forgez, Patricia The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression |
title | The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression |
title_full | The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression |
title_fullStr | The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression |
title_full_unstemmed | The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression |
title_short | The Neurotensin Receptor-1 Pathway Contributes to Human Ductal Breast Cancer Progression |
title_sort | neurotensin receptor-1 pathway contributes to human ductal breast cancer progression |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626627/ https://www.ncbi.nlm.nih.gov/pubmed/19156213 http://dx.doi.org/10.1371/journal.pone.0004223 |
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