Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors

Self-reactive B cells not controlled by receptor editing or clonal deletion may become anergic. We report that fully mature human B cells negative for surface IgM and retaining only IgD are autoreactive and functionally attenuated (referred to as naive IgD(+)IgM(−) B cells [B(ND)]). These B(ND) cell...

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Detalles Bibliográficos
Autores principales: Duty, J. Andrew, Szodoray, Peter, Zheng, Nai-Ying, Koelsch, Kristi A., Zhang, Qingzhao, Swiatkowski, Mike, Mathias, Melissa, Garman, Lori, Helms, Christina, Nakken, Britt, Smith, Kenneth, Farris, A. Darise, Wilson, Patrick C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626668/
https://www.ncbi.nlm.nih.gov/pubmed/19103878
http://dx.doi.org/10.1084/jem.20080611

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