Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ–Syk–Card9–dependent innate immune activation

Novel vaccination strategies against Mycobacterium tuberculosis (MTB) are urgently needed. The use of recombinant MTB antigens as subunit vaccines is a promising approach, but requires adjuvants that activate antigen-presenting cells (APCs) for elicitation of protective immunity. The mycobacterial c...

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Detalles Bibliográficos
Autores principales: Werninghaus, Kerstin, Babiak, Anna, Groß, Olaf, Hölscher, Christoph, Dietrich, Harald, Agger, Else Marie, Mages, Jörg, Mocsai, Attila, Schoenen, Hanne, Finger, Katrin, Nimmerjahn, Falk, Brown, Gordon D., Kirschning, Carsten, Heit, Antje, Andersen, Peter, Wagner, Hermann, Ruland, Jürgen, Lang, Roland
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2009
Materias:
Brief Definitive Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626670/
https://www.ncbi.nlm.nih.gov/pubmed/19139169
http://dx.doi.org/10.1084/jem.20081445

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