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Rosette nanotubes show low acute pulmonary toxicity in vivo

Nanotubes are being developed for a large variety of applications ranging from electronics to drug delivery. Common carbon nanotubes such as single-walled and multi-walled carbon nanotubes have been studied in the greatest detail but require solubilization and removal of catalytic contaminants such...

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Autores principales: Journeay, W Shane, Suri, Sarabjeet S, Moralez, Jesus G, Fenniri, Hicham, Singh, Baljit
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626939/
https://www.ncbi.nlm.nih.gov/pubmed/18990946
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author Journeay, W Shane
Suri, Sarabjeet S
Moralez, Jesus G
Fenniri, Hicham
Singh, Baljit
author_facet Journeay, W Shane
Suri, Sarabjeet S
Moralez, Jesus G
Fenniri, Hicham
Singh, Baljit
author_sort Journeay, W Shane
collection PubMed
description Nanotubes are being developed for a large variety of applications ranging from electronics to drug delivery. Common carbon nanotubes such as single-walled and multi-walled carbon nanotubes have been studied in the greatest detail but require solubilization and removal of catalytic contaminants such as metals prior to being introduced to biological systems for medical application. The present in vivo study characterizes the degree and nature of inflammation caused by a novel class of self-assembling rosette nanotubes, which are biologically inspired, naturally water-soluble and free of metal content upon synthesis. Upon pulmonary administration of this material we examined responses at 24 h and 7d post-exposure. An acute inflammatory response is triggered at 50 and 25 μg doses by 24 h post-exposure but an inflammatory response is not triggered by a 5 μg dose. Lung inflammation observed at a 50 μg dose at 24 h was resolving by 7d. This work suggests that novel nanostructures with biological design may negate toxicity concerns for biomedical applications of nanotubes. This study also demonstrates that water-soluble rosette nanotube structures represent low pulmonary toxicity, likely due to their biologically inspired design, and their self-assembled architecture.
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spelling pubmed-26269392009-02-18 Rosette nanotubes show low acute pulmonary toxicity in vivo Journeay, W Shane Suri, Sarabjeet S Moralez, Jesus G Fenniri, Hicham Singh, Baljit Int J Nanomedicine Original Research Nanotubes are being developed for a large variety of applications ranging from electronics to drug delivery. Common carbon nanotubes such as single-walled and multi-walled carbon nanotubes have been studied in the greatest detail but require solubilization and removal of catalytic contaminants such as metals prior to being introduced to biological systems for medical application. The present in vivo study characterizes the degree and nature of inflammation caused by a novel class of self-assembling rosette nanotubes, which are biologically inspired, naturally water-soluble and free of metal content upon synthesis. Upon pulmonary administration of this material we examined responses at 24 h and 7d post-exposure. An acute inflammatory response is triggered at 50 and 25 μg doses by 24 h post-exposure but an inflammatory response is not triggered by a 5 μg dose. Lung inflammation observed at a 50 μg dose at 24 h was resolving by 7d. This work suggests that novel nanostructures with biological design may negate toxicity concerns for biomedical applications of nanotubes. This study also demonstrates that water-soluble rosette nanotube structures represent low pulmonary toxicity, likely due to their biologically inspired design, and their self-assembled architecture. Dove Medical Press 2008-09 /pmc/articles/PMC2626939/ /pubmed/18990946 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Journeay, W Shane
Suri, Sarabjeet S
Moralez, Jesus G
Fenniri, Hicham
Singh, Baljit
Rosette nanotubes show low acute pulmonary toxicity in vivo
title Rosette nanotubes show low acute pulmonary toxicity in vivo
title_full Rosette nanotubes show low acute pulmonary toxicity in vivo
title_fullStr Rosette nanotubes show low acute pulmonary toxicity in vivo
title_full_unstemmed Rosette nanotubes show low acute pulmonary toxicity in vivo
title_short Rosette nanotubes show low acute pulmonary toxicity in vivo
title_sort rosette nanotubes show low acute pulmonary toxicity in vivo
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626939/
https://www.ncbi.nlm.nih.gov/pubmed/18990946
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