Pertussis in The Netherlands: an outbreak despite high levels of immunization with whole-cell vaccine.

In 1996, a sudden increase in pertussis incidence was reported in the Netherlands (2.1 per 100,000 in 1995, 18 per 100,000 in 1996). Although not all potential surveillance artifacts could be excluded, it is highly probable that the data reflect a true outbreak. However, the cause of this increase h...

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Detalles Bibliográficos
Autores principales: de Melker, H E, Conyn-van Spaendonck, M A, Rümke, H C, van Wijngaarden, J K, Mooi, F R, Schellekens, J F
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627603/
https://www.ncbi.nlm.nih.gov/pubmed/9204299
Descripción
Sumario:In 1996, a sudden increase in pertussis incidence was reported in the Netherlands (2.1 per 100,000 in 1995, 18 per 100,000 in 1996). Although not all potential surveillance artifacts could be excluded, it is highly probable that the data reflect a true outbreak. However, the cause of this increase has not yet been determined. Further research is directed to the severity of disease and a possible mismatch between the vaccine and the circulating Bordetella strains.

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