Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.

Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new h...

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Detalles Bibliográficos
Autores principales: McNicholl, J M, Smith, D K, Qari, S H, Hodge, T
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627644/
https://www.ncbi.nlm.nih.gov/pubmed/9284370
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author McNicholl, J M
Smith, D K
Qari, S H
Hodge, T
author_facet McNicholl, J M
Smith, D K
Qari, S H
Hodge, T
author_sort McNicholl, J M
collection PubMed
description Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. We also examine the effect of this discovery on medical and public health practices.
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spelling pubmed-26276442009-05-20 Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele. McNicholl, J M Smith, D K Qari, S H Hodge, T Emerg Infect Dis Research Article Since the late 1970s, 8.4 million people worldwide, including 1.7 million children, have died of AIDS, and an estimated 22 million people are infected with human immunodeficiency virus (HIV)(1). During 1995 and 1996, major clinical and laboratory discoveries regarding HIV pathogenesis provided new hope for the prevention and treatment of HIV infection. One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. We also examine the effect of this discovery on medical and public health practices. Centers for Disease Control and Prevention 1997 /pmc/articles/PMC2627644/ /pubmed/9284370 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Article
McNicholl, J M
Smith, D K
Qari, S H
Hodge, T
Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
title Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
title_full Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
title_fullStr Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
title_full_unstemmed Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
title_short Host genes and HIV: the role of the chemokine receptor gene CCR5 and its allele.
title_sort host genes and hiv: the role of the chemokine receptor gene ccr5 and its allele.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627644/
https://www.ncbi.nlm.nih.gov/pubmed/9284370
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