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Influence of host genetics on the severity of coccidioidomycosis.

Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants include...

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Autores principales: Louie, L, Ng, S, Hajjeh, R, Johnson, R, Vugia, D, Werner, S B, Talbot, R, Klitz, W
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627717/
https://www.ncbi.nlm.nih.gov/pubmed/10511523
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author Louie, L
Ng, S
Hajjeh, R
Johnson, R
Vugia, D
Werner, S B
Talbot, R
Klitz, W
author_facet Louie, L
Ng, S
Hajjeh, R
Johnson, R
Vugia, D
Werner, S B
Talbot, R
Klitz, W
author_sort Louie, L
collection PubMed
description Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants included African-American, Caucasian, and Hispanic persons with mild or severe disseminated coccidioidomycosis from Kern County, California. Among Hispanics, predisposition to symptomatic disease and severe disseminated disease is associated with blood types A and B, respectively. The HLA class II DRB1*1301 allele marks a pre-disposition to severe disseminated disease in each of the three groups. Reduced risk for severe disease is associated with DRB1*0301-DQB1*0201 among Caucasians and Hispanics and with DRB1*1501-DQB1*0602 among African-Americans. These data support the hypothesis that host genes, in particular HLA class II and the ABO blood group, influence susceptibility to severe coccidioidomycosis.
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spelling pubmed-26277172009-05-20 Influence of host genetics on the severity of coccidioidomycosis. Louie, L Ng, S Hajjeh, R Johnson, R Vugia, D Werner, S B Talbot, R Klitz, W Emerg Infect Dis Research Article Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants included African-American, Caucasian, and Hispanic persons with mild or severe disseminated coccidioidomycosis from Kern County, California. Among Hispanics, predisposition to symptomatic disease and severe disseminated disease is associated with blood types A and B, respectively. The HLA class II DRB1*1301 allele marks a pre-disposition to severe disseminated disease in each of the three groups. Reduced risk for severe disease is associated with DRB1*0301-DQB1*0201 among Caucasians and Hispanics and with DRB1*1501-DQB1*0602 among African-Americans. These data support the hypothesis that host genes, in particular HLA class II and the ABO blood group, influence susceptibility to severe coccidioidomycosis. Centers for Disease Control and Prevention 1999 /pmc/articles/PMC2627717/ /pubmed/10511523 Text en
spellingShingle Research Article
Louie, L
Ng, S
Hajjeh, R
Johnson, R
Vugia, D
Werner, S B
Talbot, R
Klitz, W
Influence of host genetics on the severity of coccidioidomycosis.
title Influence of host genetics on the severity of coccidioidomycosis.
title_full Influence of host genetics on the severity of coccidioidomycosis.
title_fullStr Influence of host genetics on the severity of coccidioidomycosis.
title_full_unstemmed Influence of host genetics on the severity of coccidioidomycosis.
title_short Influence of host genetics on the severity of coccidioidomycosis.
title_sort influence of host genetics on the severity of coccidioidomycosis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627717/
https://www.ncbi.nlm.nih.gov/pubmed/10511523
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