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Influence of host genetics on the severity of coccidioidomycosis.
Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants include...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Centers for Disease Control and Prevention
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627717/ https://www.ncbi.nlm.nih.gov/pubmed/10511523 |
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author | Louie, L Ng, S Hajjeh, R Johnson, R Vugia, D Werner, S B Talbot, R Klitz, W |
author_facet | Louie, L Ng, S Hajjeh, R Johnson, R Vugia, D Werner, S B Talbot, R Klitz, W |
author_sort | Louie, L |
collection | PubMed |
description | Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants included African-American, Caucasian, and Hispanic persons with mild or severe disseminated coccidioidomycosis from Kern County, California. Among Hispanics, predisposition to symptomatic disease and severe disseminated disease is associated with blood types A and B, respectively. The HLA class II DRB1*1301 allele marks a pre-disposition to severe disseminated disease in each of the three groups. Reduced risk for severe disease is associated with DRB1*0301-DQB1*0201 among Caucasians and Hispanics and with DRB1*1501-DQB1*0602 among African-Americans. These data support the hypothesis that host genes, in particular HLA class II and the ABO blood group, influence susceptibility to severe coccidioidomycosis. |
format | Text |
id | pubmed-2627717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-26277172009-05-20 Influence of host genetics on the severity of coccidioidomycosis. Louie, L Ng, S Hajjeh, R Johnson, R Vugia, D Werner, S B Talbot, R Klitz, W Emerg Infect Dis Research Article Coccidioidomycosis, a mild flulike illness in approximately 40% of infected persons, progresses to severe pulmonary or disseminated disease in 1% to 10% of symptomatic cases. We examined host genetic influences on disease severity among class II HLA loci and the ABO blood group. Participants included African-American, Caucasian, and Hispanic persons with mild or severe disseminated coccidioidomycosis from Kern County, California. Among Hispanics, predisposition to symptomatic disease and severe disseminated disease is associated with blood types A and B, respectively. The HLA class II DRB1*1301 allele marks a pre-disposition to severe disseminated disease in each of the three groups. Reduced risk for severe disease is associated with DRB1*0301-DQB1*0201 among Caucasians and Hispanics and with DRB1*1501-DQB1*0602 among African-Americans. These data support the hypothesis that host genes, in particular HLA class II and the ABO blood group, influence susceptibility to severe coccidioidomycosis. Centers for Disease Control and Prevention 1999 /pmc/articles/PMC2627717/ /pubmed/10511523 Text en |
spellingShingle | Research Article Louie, L Ng, S Hajjeh, R Johnson, R Vugia, D Werner, S B Talbot, R Klitz, W Influence of host genetics on the severity of coccidioidomycosis. |
title | Influence of host genetics on the severity of coccidioidomycosis. |
title_full | Influence of host genetics on the severity of coccidioidomycosis. |
title_fullStr | Influence of host genetics on the severity of coccidioidomycosis. |
title_full_unstemmed | Influence of host genetics on the severity of coccidioidomycosis. |
title_short | Influence of host genetics on the severity of coccidioidomycosis. |
title_sort | influence of host genetics on the severity of coccidioidomycosis. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627717/ https://www.ncbi.nlm.nih.gov/pubmed/10511523 |
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