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Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia

BACKGROUND: Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES: In this case–control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leuk...

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Autores principales: Scélo, Ghislaine, Metayer, Catherine, Zhang, Luoping, Wiemels, Joseph L., Aldrich, Melinda C., Selvin, Steve, Month, Stacy, Smith, Martyn T., Buffler, Patricia A.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627857/
https://www.ncbi.nlm.nih.gov/pubmed/19165400
http://dx.doi.org/10.1289/ehp.11927
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author Scélo, Ghislaine
Metayer, Catherine
Zhang, Luoping
Wiemels, Joseph L.
Aldrich, Melinda C.
Selvin, Steve
Month, Stacy
Smith, Martyn T.
Buffler, Patricia A.
author_facet Scélo, Ghislaine
Metayer, Catherine
Zhang, Luoping
Wiemels, Joseph L.
Aldrich, Melinda C.
Selvin, Steve
Month, Stacy
Smith, Martyn T.
Buffler, Patricia A.
author_sort Scélo, Ghislaine
collection PubMed
description BACKGROUND: Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES: In this case–control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. METHODS: We based our analyses on 550 cases of acute lymphoblastic leukemia (ALL), 100 cases of acute myeloid leukemia (AML), and one or two controls per case individually matched for sex, age, Hispanic status, and race. We conducted further analyses by cytogenetic subtype. We used conditional logistic regression techniques to adjust for income. RESULTS: ALL risk was significantly associated with paint exposure [odds ratio (OR) = 1.65; 95% confidence interval (CI), 1.26–2.15], with a higher risk observed when paint was used postnatally, by a person other than the mother, or frequently. The association was restricted to leukemia with translocations between chromosomes 12 and 21 (OR = 4.16; 95% CI, 1.66–10.4). We found no significant association between solvent use and ALL risk overall (OR = 1.15; 95% CI, 0.87–1.51) or for various cytogenetic subtypes, but we observed a significant association in the 2.0- to 5.9-year age group (OR = 1.55; 95% CI, 1.07–2.25). In contrast, a significant increased risk for AML was associated with solvent (OR = 2.54; 95% CI, 1.19–5.42) but not with paint exposure (OR = 0.64; 95% CI, 0.32–1.25). CONCLUSIONS: The association of ALL risk with paint exposure was strong, consistent with a causal relationship, but further studies are needed to confirm the association of ALL and AML risk with solvent exposure.
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spelling pubmed-26278572009-01-22 Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia Scélo, Ghislaine Metayer, Catherine Zhang, Luoping Wiemels, Joseph L. Aldrich, Melinda C. Selvin, Steve Month, Stacy Smith, Martyn T. Buffler, Patricia A. Environ Health Perspect Research BACKGROUND: Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES: In this case–control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. METHODS: We based our analyses on 550 cases of acute lymphoblastic leukemia (ALL), 100 cases of acute myeloid leukemia (AML), and one or two controls per case individually matched for sex, age, Hispanic status, and race. We conducted further analyses by cytogenetic subtype. We used conditional logistic regression techniques to adjust for income. RESULTS: ALL risk was significantly associated with paint exposure [odds ratio (OR) = 1.65; 95% confidence interval (CI), 1.26–2.15], with a higher risk observed when paint was used postnatally, by a person other than the mother, or frequently. The association was restricted to leukemia with translocations between chromosomes 12 and 21 (OR = 4.16; 95% CI, 1.66–10.4). We found no significant association between solvent use and ALL risk overall (OR = 1.15; 95% CI, 0.87–1.51) or for various cytogenetic subtypes, but we observed a significant association in the 2.0- to 5.9-year age group (OR = 1.55; 95% CI, 1.07–2.25). In contrast, a significant increased risk for AML was associated with solvent (OR = 2.54; 95% CI, 1.19–5.42) but not with paint exposure (OR = 0.64; 95% CI, 0.32–1.25). CONCLUSIONS: The association of ALL risk with paint exposure was strong, consistent with a causal relationship, but further studies are needed to confirm the association of ALL and AML risk with solvent exposure. National Institute of Environmental Health Sciences 2009-01 2008-10-10 /pmc/articles/PMC2627857/ /pubmed/19165400 http://dx.doi.org/10.1289/ehp.11927 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Scélo, Ghislaine
Metayer, Catherine
Zhang, Luoping
Wiemels, Joseph L.
Aldrich, Melinda C.
Selvin, Steve
Month, Stacy
Smith, Martyn T.
Buffler, Patricia A.
Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
title Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
title_full Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
title_fullStr Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
title_full_unstemmed Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
title_short Household Exposure to Paint and Petroleum Solvents, Chromosomal Translocations, and the Risk of Childhood Leukemia
title_sort household exposure to paint and petroleum solvents, chromosomal translocations, and the risk of childhood leukemia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627857/
https://www.ncbi.nlm.nih.gov/pubmed/19165400
http://dx.doi.org/10.1289/ehp.11927
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