A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors

We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were e...

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Autores principales: Chang, Joo Hee, Kwon, Young Se, Kim, Bok Ki, Son, Byong Kwan, Lee, Jee Eun, Lim, Dae Hyun, Kim, Soon Ki, Kim, Joon Mi, Kang, Sung Kil
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2008
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628021/
https://www.ncbi.nlm.nih.gov/pubmed/19108034
http://dx.doi.org/10.3349/ymj.2008.49.6.1055
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author Chang, Joo Hee
Kwon, Young Se
Kim, Bok Ki
Son, Byong Kwan
Lee, Jee Eun
Lim, Dae Hyun
Kim, Soon Ki
Kim, Joon Mi
Kang, Sung Kil
author_facet Chang, Joo Hee
Kwon, Young Se
Kim, Bok Ki
Son, Byong Kwan
Lee, Jee Eun
Lim, Dae Hyun
Kim, Soon Ki
Kim, Joon Mi
Kang, Sung Kil
author_sort Chang, Joo Hee
collection PubMed
description We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were elevated on admission without any past medical history. After treatment with azithromycin for 3 days, pneumonia improved, but the hepatitis was acutely aggravated. Partial thromboplastin time (PTT) was prolonged and depression of multiple coagulation factors developed. Liver biopsy revealed features consistent with acute hepatitis. A week later, liver enzymes were nearly normalized spontaneously. Normalization of prolonged PTT and coagulation factors were also observed several months later. This may be the first case of transient depression of multiple coagulation factors associated with M. pneumoniae infection.
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spelling pubmed-26280212009-02-02 A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors Chang, Joo Hee Kwon, Young Se Kim, Bok Ki Son, Byong Kwan Lee, Jee Eun Lim, Dae Hyun Kim, Soon Ki Kim, Joon Mi Kang, Sung Kil Yonsei Med J Case Report We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were elevated on admission without any past medical history. After treatment with azithromycin for 3 days, pneumonia improved, but the hepatitis was acutely aggravated. Partial thromboplastin time (PTT) was prolonged and depression of multiple coagulation factors developed. Liver biopsy revealed features consistent with acute hepatitis. A week later, liver enzymes were nearly normalized spontaneously. Normalization of prolonged PTT and coagulation factors were also observed several months later. This may be the first case of transient depression of multiple coagulation factors associated with M. pneumoniae infection. Yonsei University College of Medicine 2008-12-31 2008-12-31 /pmc/articles/PMC2628021/ /pubmed/19108034 http://dx.doi.org/10.3349/ymj.2008.49.6.1055 Text en Copyright © 2008 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chang, Joo Hee
Kwon, Young Se
Kim, Bok Ki
Son, Byong Kwan
Lee, Jee Eun
Lim, Dae Hyun
Kim, Soon Ki
Kim, Joon Mi
Kang, Sung Kil
A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
title A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
title_full A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
title_fullStr A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
title_full_unstemmed A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
title_short A Case of Acute Hepatitis with Mycoplasma pneumoniae Infection and Transient Depression of Multiple Coagulation Factors
title_sort case of acute hepatitis with mycoplasma pneumoniae infection and transient depression of multiple coagulation factors
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628021/
https://www.ncbi.nlm.nih.gov/pubmed/19108034
http://dx.doi.org/10.3349/ymj.2008.49.6.1055
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