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Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients
PURPOSE: Hypertensive response to exercise (HRE) is known to be an adverse prognostic factor for future cardiovascular events and may be associated to endothelial dysfunction. Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hype...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Yonsei University College of Medicine
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628106/ https://www.ncbi.nlm.nih.gov/pubmed/17594145 http://dx.doi.org/10.3349/ymj.2007.48.3.389 |
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author | Kim, Jung-Sun Cho, Jung Rae Park, Sungha Shim, Jaemin Kim, Jin-Bae Cho, Deok-Kyu Shin, Hyun-Joon Park, Chan Mi Ko, Young-Guk Ha, Jong-Won Choi, Donghoon Rim, Se-Joong Jang, Yangsoo Chung, Namsik |
author_facet | Kim, Jung-Sun Cho, Jung Rae Park, Sungha Shim, Jaemin Kim, Jin-Bae Cho, Deok-Kyu Shin, Hyun-Joon Park, Chan Mi Ko, Young-Guk Ha, Jong-Won Choi, Donghoon Rim, Se-Joong Jang, Yangsoo Chung, Namsik |
author_sort | Kim, Jung-Sun |
collection | PubMed |
description | PURPOSE: Hypertensive response to exercise (HRE) is known to be an adverse prognostic factor for future cardiovascular events and may be associated to endothelial dysfunction. Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension. In this study, we hypothesize that the polymorphism may be associated with inherent difference in endothelial response to exercise. PATIENTS AND METHODS: Two hundred sixty nine patients who underwent treadmill test were enrolled in this study; 77 patients (mean age 55.8 ± 9.4 years) had hypertensive response (peak systolic BP of ≥ 210mmHg in men and ≥ 190mmHg in women). Pulse wave velocity (PWV) was measured on 153 patients of them. The Glu298Asp exchange in exon 7 was determined by the methods of single base extension with amplifying primers and probes for TaqMan. RESULTS: The percentages of the GG, GT and TT genotypes were 81.0, 18.6 and 0.4%, respectively. The presence of GT or TT genotype was independently associated with prevention of HRE when controlled for age, sex, baseline systolic BP and homeostatic model assessment (HOMA) index (OR = 0.35, p = 0.016). Subgroup analysis showed that preventive effect for HRE of T allele was significant in females (p < 0.001) and patients without insulin resistance (p = 0.009). CONCLUSION: In our study, eNOS Glu298Asp polymorphism was significantly associated with HRE. This result suggests that the presence of T allele of the Glu298Asp polymorphism may be a favorable factor to in preventing HRE, especially in female and patients without insulin resistance. |
format | Text |
id | pubmed-2628106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-26281062009-02-02 Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients Kim, Jung-Sun Cho, Jung Rae Park, Sungha Shim, Jaemin Kim, Jin-Bae Cho, Deok-Kyu Shin, Hyun-Joon Park, Chan Mi Ko, Young-Guk Ha, Jong-Won Choi, Donghoon Rim, Se-Joong Jang, Yangsoo Chung, Namsik Yonsei Med J Original Article PURPOSE: Hypertensive response to exercise (HRE) is known to be an adverse prognostic factor for future cardiovascular events and may be associated to endothelial dysfunction. Previous studies regarding endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism focused upon its relation to hypertension. In this study, we hypothesize that the polymorphism may be associated with inherent difference in endothelial response to exercise. PATIENTS AND METHODS: Two hundred sixty nine patients who underwent treadmill test were enrolled in this study; 77 patients (mean age 55.8 ± 9.4 years) had hypertensive response (peak systolic BP of ≥ 210mmHg in men and ≥ 190mmHg in women). Pulse wave velocity (PWV) was measured on 153 patients of them. The Glu298Asp exchange in exon 7 was determined by the methods of single base extension with amplifying primers and probes for TaqMan. RESULTS: The percentages of the GG, GT and TT genotypes were 81.0, 18.6 and 0.4%, respectively. The presence of GT or TT genotype was independently associated with prevention of HRE when controlled for age, sex, baseline systolic BP and homeostatic model assessment (HOMA) index (OR = 0.35, p = 0.016). Subgroup analysis showed that preventive effect for HRE of T allele was significant in females (p < 0.001) and patients without insulin resistance (p = 0.009). CONCLUSION: In our study, eNOS Glu298Asp polymorphism was significantly associated with HRE. This result suggests that the presence of T allele of the Glu298Asp polymorphism may be a favorable factor to in preventing HRE, especially in female and patients without insulin resistance. Yonsei University College of Medicine 2007-06-30 2007-06-20 /pmc/articles/PMC2628106/ /pubmed/17594145 http://dx.doi.org/10.3349/ymj.2007.48.3.389 Text en Copyright © 2007 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jung-Sun Cho, Jung Rae Park, Sungha Shim, Jaemin Kim, Jin-Bae Cho, Deok-Kyu Shin, Hyun-Joon Park, Chan Mi Ko, Young-Guk Ha, Jong-Won Choi, Donghoon Rim, Se-Joong Jang, Yangsoo Chung, Namsik Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients |
title | Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients |
title_full | Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients |
title_fullStr | Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients |
title_full_unstemmed | Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients |
title_short | Endothelial Nitric Oxide Synthase Glu298Asp Gene Polymorphism is Associated with Hypertensive Response to Exercise in Well-Controlled Hypertensive Patients |
title_sort | endothelial nitric oxide synthase glu298asp gene polymorphism is associated with hypertensive response to exercise in well-controlled hypertensive patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628106/ https://www.ncbi.nlm.nih.gov/pubmed/17594145 http://dx.doi.org/10.3349/ymj.2007.48.3.389 |
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