Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation

We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein-Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and...

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Detalles Bibliográficos
Autores principales: Chang, Jae Yong, Kim, Soo-Chan
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628108/
https://www.ncbi.nlm.nih.gov/pubmed/17461533
http://dx.doi.org/10.3349/ymj.2007.48.2.317
Descripción
Sumario:We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein-Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English-language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.

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