Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation

We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein-Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and...

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Detalles Bibliográficos
Autores principales: Chang, Jae Yong, Kim, Soo-Chan
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2007
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628108/
https://www.ncbi.nlm.nih.gov/pubmed/17461533
http://dx.doi.org/10.3349/ymj.2007.48.2.317
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author Chang, Jae Yong
Kim, Soo-Chan
author_facet Chang, Jae Yong
Kim, Soo-Chan
author_sort Chang, Jae Yong
collection PubMed
description We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein-Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English-language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients.
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spelling pubmed-26281082009-02-02 Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation Chang, Jae Yong Kim, Soo-Chan Yonsei Med J Case Report We describe a 59-year-old female with severe anticonvulsant hypersensitivity syndrome (AHS) associated with Epstein-Barr virus (EBV) infection. The causative drug was speculated to be carbamazepine. Recurrent EBV infection was demonstrated by the presence of anti-EBV early antigen IgM antibodies and anti-EBV nuclear antigen IgG antibodies. To our knowledge, only one case of drug hypersensitivity syndrome (DHS) associated with EBV has been reported in the English-language literature. Our case is the second report of EBV-associated DHS, which suggests that EBV infection may contribute to the pathogenesis of AHS in a few patients. Yonsei University College of Medicine 2007-04-30 2007-04-30 /pmc/articles/PMC2628108/ /pubmed/17461533 http://dx.doi.org/10.3349/ymj.2007.48.2.317 Text en Copyright © 2007 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chang, Jae Yong
Kim, Soo-Chan
Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
title Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
title_full Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
title_fullStr Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
title_full_unstemmed Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
title_short Anticonvulsant Hypersensitivity Syndrome Associated with Epstein-Barr Virus Reactivation
title_sort anticonvulsant hypersensitivity syndrome associated with epstein-barr virus reactivation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628108/
https://www.ncbi.nlm.nih.gov/pubmed/17461533
http://dx.doi.org/10.3349/ymj.2007.48.2.317
work_keys_str_mv AT changjaeyong anticonvulsanthypersensitivitysyndromeassociatedwithepsteinbarrvirusreactivation
AT kimsoochan anticonvulsanthypersensitivitysyndromeassociatedwithepsteinbarrvirusreactivation

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