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What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?

PURPOSE: To test the hypothesis that chronic subdural hematoma (CSDH) enlarges by the causative factors, this study has performed. MATERIALS AND METHODS: In 10 patients with CSDH, coagulation factors in venous blood taken at the time of surgery and hematomic contents aspirated from the CSDH were stu...

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Autores principales: Shim, Yu Shik, Park, Chong Oon, Hyun, Dong Kun, Park, Hyung Chun, Yoon, Seung Hwan
Formato: Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628130/
https://www.ncbi.nlm.nih.gov/pubmed/17461518
http://dx.doi.org/10.3349/ymj.2007.48.2.210
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author Shim, Yu Shik
Park, Chong Oon
Hyun, Dong Kun
Park, Hyung Chun
Yoon, Seung Hwan
author_facet Shim, Yu Shik
Park, Chong Oon
Hyun, Dong Kun
Park, Hyung Chun
Yoon, Seung Hwan
author_sort Shim, Yu Shik
collection PubMed
description PURPOSE: To test the hypothesis that chronic subdural hematoma (CSDH) enlarges by the causative factors, this study has performed. MATERIALS AND METHODS: In 10 patients with CSDH, coagulation factors in venous blood taken at the time of surgery and hematomic contents aspirated from the CSDH were studied, using both laboratory assays and microscopy. RESULTS: When compared to the range of normal plasma, the hematoma fluids demonstrated a marked reduction in factor II, V, VII, VIII, and X, moderate reduction of factors IX and XI, and slight reduction of factor XII. Activated protein C and antithrombin III levels were decreased. The FDP (Fibrinogen Degradation Product) levels in chronic subdural hematoma were extremely high. The endothelial cells of the macrocapillaries (also called "sinusoid") showed numerous gap junctions between adjacent endothelial cells and a thinness or absence of the basement membrane, suggesting that the macrocapillaries are very fragile and susceptible to bleeding. CONCLUSION: Excessive coagulation in the hematoma, predominantly via the extrinsic clotting pathway, local hyperfibrinolysis, transmitted pulsations, and characteristics of the macrocapillaries play an important role in the leakage of blood and the enlargement of CSDH.
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spelling pubmed-26281302009-02-02 What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma? Shim, Yu Shik Park, Chong Oon Hyun, Dong Kun Park, Hyung Chun Yoon, Seung Hwan Yonsei Med J Original Article PURPOSE: To test the hypothesis that chronic subdural hematoma (CSDH) enlarges by the causative factors, this study has performed. MATERIALS AND METHODS: In 10 patients with CSDH, coagulation factors in venous blood taken at the time of surgery and hematomic contents aspirated from the CSDH were studied, using both laboratory assays and microscopy. RESULTS: When compared to the range of normal plasma, the hematoma fluids demonstrated a marked reduction in factor II, V, VII, VIII, and X, moderate reduction of factors IX and XI, and slight reduction of factor XII. Activated protein C and antithrombin III levels were decreased. The FDP (Fibrinogen Degradation Product) levels in chronic subdural hematoma were extremely high. The endothelial cells of the macrocapillaries (also called "sinusoid") showed numerous gap junctions between adjacent endothelial cells and a thinness or absence of the basement membrane, suggesting that the macrocapillaries are very fragile and susceptible to bleeding. CONCLUSION: Excessive coagulation in the hematoma, predominantly via the extrinsic clotting pathway, local hyperfibrinolysis, transmitted pulsations, and characteristics of the macrocapillaries play an important role in the leakage of blood and the enlargement of CSDH. Yonsei University College of Medicine 2007-04-30 2007-04-30 /pmc/articles/PMC2628130/ /pubmed/17461518 http://dx.doi.org/10.3349/ymj.2007.48.2.210 Text en Copyright © 2007 The Yonsei University College of Medicine http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shim, Yu Shik
Park, Chong Oon
Hyun, Dong Kun
Park, Hyung Chun
Yoon, Seung Hwan
What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?
title What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?
title_full What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?
title_fullStr What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?
title_full_unstemmed What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?
title_short What are the Causative Factors for a Slow, Progressive Enlargement of a Chronic Subdural Hematoma?
title_sort what are the causative factors for a slow, progressive enlargement of a chronic subdural hematoma?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628130/
https://www.ncbi.nlm.nih.gov/pubmed/17461518
http://dx.doi.org/10.3349/ymj.2007.48.2.210
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