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The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain
BACKGROUND: DSB, the 3-O-(3',3'dimethylsuccinyl) derivative of betulinic acid, blocks the last step of protease-mediated processing of HIV-1 Gag precursor (Pr55Gag), which leads to immature, noninfectious virions. When administered to Pr55Gag-expressing insect cells (Sf9), DSB inhibits the...
Autores principales: | DaFonseca, Sandrina, Coric, Pascale, Gay, Bernard, Hong, Saw See, Bouaziz, Serge, Boulanger, Pierre |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628355/ https://www.ncbi.nlm.nih.gov/pubmed/19105849 http://dx.doi.org/10.1186/1743-422X-5-162 |
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