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Live immunisation against Theileria parva: containing or spreading the disease?
Although a live vaccine against Theileria parva has been available for over 30 years, concerns that vaccine strains can become established in resident tick populations have impeded its uptake in endemic areas. Recently, Oura et al. have examined the persistence of vaccine strains in immunised cattle...
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Formato: | Texto |
Lenguaje: | English |
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Elsevier Science
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628564/ https://www.ncbi.nlm.nih.gov/pubmed/17964219 http://dx.doi.org/10.1016/j.pt.2007.09.002 |
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author | McKeever, Declan J. |
author_facet | McKeever, Declan J. |
author_sort | McKeever, Declan J. |
collection | PubMed |
description | Although a live vaccine against Theileria parva has been available for over 30 years, concerns that vaccine strains can become established in resident tick populations have impeded its uptake in endemic areas. Recently, Oura et al. have examined the persistence of vaccine strains in immunised cattle using polymorphic genomic markers. They confirm that elements of the vaccine establish a carrier state in vaccinated animals and present evidence that alleles associated with vaccine strains emerge in co-grazing non-vaccinated cattle. However, the epidemiological impact of these observations might be tempered by extensive recombination of co-ingested strains in the tick vector. |
format | Text |
id | pubmed-2628564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26285642009-01-19 Live immunisation against Theileria parva: containing or spreading the disease? McKeever, Declan J. Trends Parasitol Update
Research Focus Although a live vaccine against Theileria parva has been available for over 30 years, concerns that vaccine strains can become established in resident tick populations have impeded its uptake in endemic areas. Recently, Oura et al. have examined the persistence of vaccine strains in immunised cattle using polymorphic genomic markers. They confirm that elements of the vaccine establish a carrier state in vaccinated animals and present evidence that alleles associated with vaccine strains emerge in co-grazing non-vaccinated cattle. However, the epidemiological impact of these observations might be tempered by extensive recombination of co-ingested strains in the tick vector. Elsevier Science 2007-12 /pmc/articles/PMC2628564/ /pubmed/17964219 http://dx.doi.org/10.1016/j.pt.2007.09.002 Text en © 2007 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license |
spellingShingle | Update
Research Focus McKeever, Declan J. Live immunisation against Theileria parva: containing or spreading the disease? |
title | Live immunisation against Theileria parva: containing or spreading the disease? |
title_full | Live immunisation against Theileria parva: containing or spreading the disease? |
title_fullStr | Live immunisation against Theileria parva: containing or spreading the disease? |
title_full_unstemmed | Live immunisation against Theileria parva: containing or spreading the disease? |
title_short | Live immunisation against Theileria parva: containing or spreading the disease? |
title_sort | live immunisation against theileria parva: containing or spreading the disease? |
topic | Update
Research Focus |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628564/ https://www.ncbi.nlm.nih.gov/pubmed/17964219 http://dx.doi.org/10.1016/j.pt.2007.09.002 |
work_keys_str_mv | AT mckeeverdeclanj liveimmunisationagainsttheileriaparvacontainingorspreadingthedisease |