Cargando…

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

OBJECTIVE—The aim of this study was to find an effective treatment for the genetic form of diabetes that is present in some Huntington's disease patients and in Huntington's disease mouse models. Huntington's disease is a neurodegenerative disorder caused by a polyglutamine expansion...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Bronwen, Golden, Erin, Carlson, Olga D., Pistell, Paul, Zhou, Jie, Kim, Wook, Frank, Brittany P., Thomas, Sam, Chadwick, Wayne A., Greig, Nigel H., Bates, Gillian P., Sathasivam, Kirupa, Bernier, Michel, Maudsley, Stuart, Mattson, Mark P., Egan, Josephine M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628604/ https://www.ncbi.nlm.nih.gov/pubmed/18984744 http://dx.doi.org/10.2337/db08-0799

Ejemplares similares

Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models
por: Mason, Michael A., et al.
Publicado: (2020)

Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease
por: Sathasivam, Kirupa, et al.
Publicado: (2010)

Circulating Brain-Derived Neurotrophic Factor and Indices of Metabolic and Cardiovascular Health: Data from the Baltimore Longitudinal Study of Aging
por: Golden, Erin, et al.
Publicado: (2010)

Metabolic and hormonal signatures in pre-manifest and manifest Huntington's disease patients
por: Wang, Rui, et al.
Publicado: (2014)

Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease
por: Zhou, Ya, et al.
Publicado: (2021)

Alternative processing of human HTT mRNA with implications for Huntington’s disease therapeutics
por: Fienko, Sandra, et al.
Publicado: (2022)

Conserved and Differential Effects of Dietary Energy Intake on the Hippocampal Transcriptomes of Females and Males
por: Martin, Bronwen, et al.
Publicado: (2008)

Vasoactive Intestinal Peptide–Null Mice Demonstrate Enhanced Sweet Taste Preference, Dysglycemia, and Reduced Taste Bud Leptin Receptor Expression
por: Martin, Bronwen, et al.
Publicado: (2010)

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis
por: Li, Yazhou, et al.
Publicado: (2012)

Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model
por: Landles, Christian, et al.
Publicado: (2020)

Exendin-4 Ameliorates Traumatic Brain Injury-Induced Cognitive Impairment in Rats
por: Eakin, Katharine, et al.
Publicado: (2013)

Gonadal Transcriptome Alterations in Response to Dietary Energy Intake: Sensing the Reproductive Environment
por: Martin, Bronwen, et al.
Publicado: (2009)

Glycemic responses to strenuous training in male professional cyclists with type 1 diabetes: a prospective observational study
por: McCarthy, Olivia, et al.
Publicado: (2020)

A novel approach to glycemic control in type 2 diabetes mellitus, partial jejunal diversion: pre-clinical to clinical pathway
por: Fried, Martin, et al.
Publicado: (2017)

Antecedent Hypoglycemia Impairs Autonomic Cardiovascular Function: Implications for Rigorous Glycemic Control
por: Adler, Gail K., et al.
Publicado: (2009)

Complex and Multidimensional Lipid Raft Alterations in a Murine Model of Alzheimer's Disease
por: Chadwick, Wayne, et al.
Publicado: (2010)

Altered Hypothalamic Protein Expression in a Rat Model of Huntington's Disease
por: Cong, Wei-na, et al.
Publicado: (2012)

Distinct Neuronal Projections From the Hypothalamic Ventromedial Nucleus Mediate Glycemic and Behavioral Effects
por: Faber, Chelsea L., et al.
Publicado: (2018)

Correction: Altered Hypothalamic Protein Expression in a Rat Model of Huntington's Disease
por: Cong, Wei-na, et al.
Publicado: (2012)

Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington’s disease mice
por: Bondulich, Marie K., et al.
Publicado: (2017)

A common gene expression signature in Huntington’s disease patient brain regions
por: Neueder, Andreas, et al.
Publicado: (2014)

Plasma BDNF Is Associated with Age-Related White Matter Atrophy but Not with Cognitive Function in Older, Non-Demented Adults
por: Driscoll, Ira, et al.
Publicado: (2012)

Pancreas++: Automated Quantification of Pancreatic Islet Cells in Microscopy Images
por: Chen, Hongyu, et al.
Publicado: (2013)

Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism Through AKT Activation
por: McMurphy, Travis B., et al.
Publicado: (2017)

Exendin‐4 analogs in insulinoma theranostics
por: Jansen, Tom.J.P., et al.
Publicado: (2019)

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
por: Osmand, Alexander P., et al.
Publicado: (2016)

Lactobacillus salivarius AP-32 and Lactobacillus reuteri GL-104 decrease glycemic levels and attenuate diabetes-mediated liver and kidney injury in db/db mice
por: Hsieh, Pei-Shan, et al.
Publicado: (2020)

Glycemic Disturbances in Pheochromocytoma and Paraganglioma
por: Ronen, Joshua A, et al.
Publicado: (2019)

Flexible treatment of gestational diabetes mellitus adjusted according to intrauterine fetal growth versus treatment according to strict maternal glycemic parameters: a randomized clinical trial
por: Fernández-López, Manuela, et al.
Publicado: (2022)

The Impact of a Nursing Strike on Glycemic Control in Hospitalized Patients with Diabetes
por: Sheahan, Kelsey H, et al.
Publicado: (2021)

Exendin-4 for Parkinson's disease
por: Esparza-Salazar, Felipe de Jesús, et al.
Publicado: (2021)

An Unanticipated Worsening of Glycemic Control Following a Mild COVID-19 Infection
por: Hardin, Ellen M, et al.
Publicado: (2022)

Plurigon: three dimensional visualization and classification of high-dimensionality data
por: Martin, Bronwen, et al.
Publicado: (2013)

Cell Reprogramming to Model Huntington’s Disease: A Comprehensive Review
por: Monk, Ruth, et al.
Publicado: (2021)

Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease
por: Benn, Caroline L, et al.
Publicado: (2008)

The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease
por: Bett, John S., et al.
Publicado: (2009)

New Radiolabeled Exendin Analogues Show Reduced Renal Retention
por: Joosten, Lieke, et al.
Publicado: (2023)

Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington’s disease mice
por: Griffioen, Kathleen, et al.
Publicado: (2018)

Glycemic variability and cardiovascular disease in patients with type 2 diabetes
por: Martinez, Marcela, et al.
Publicado: (2021)

Effects of Electroconvulsive Therapy on Glycemic Control in Type 1 Diabetes
por: Stefan, Simona, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_i2m4mm8sf43r4nbsmfac63rh6l