Cargando…

Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway

OBJECTIVE—SIRT1, a class III histone/protein deacetylase, is known to interfere with the nuclear factor-κB (NF-κB) signaling pathway and thereby has an anti-inflammatory function. Because of the central role of NF-κB in cytokine-mediated pancreatic β-cell damage, we postulated that SIRT1 might work...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Ji-Hyun, Song, Mi-Young, Song, Eun-Kyung, Kim, Eun-Kyung, Moon, Woo Sung, Han, Myung-Kwan, Park, Jin-Woo, Kwon, Kang-Beom, Park, Byung-Hyun
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2009
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628607/ https://www.ncbi.nlm.nih.gov/pubmed/19008341 http://dx.doi.org/10.2337/db07-1795

Ejemplares similares

Myeloid Deletion of SIRT1 Aggravates Serum Transfer Arthritis in Mice via Nuclear Factor-κB Activation
por: Hah, Young-Sool, et al.
Publicado: (2014)

Pharmacological Activation of Sirt1 Ameliorates Polyglutamine-Induced Toxicity through the Regulation of Autophagy
por: Shin, Bae Hyun, et al.
Publicado: (2013)

Effects of dietary protein levels on performance, nitrogen excretion, and odor emission of growing pullets and laying hens
por: Heo, Yun-Ji, et al.
Publicado: (2023)

Interleukin-17 and Interleukin-22 Induced Proinflammatory Cytokine Production in Keratinocytes via Inhibitor of Nuclear Factor κB Kinase-α Expression
por: Cho, Kyung-Ah, et al.
Publicado: (2012)

Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
por: Yoo, Chae-Hwa, et al.
Publicado: (2014)

Thyroid Transcription Factor‐1 Regulates Feeding Behavior via Melanocortin Pathway in the Hypothalamus
por: Kim, Jae Geun, et al.
Publicado: (2011)

Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-κB-signaling Pathway
por: Kim, Bora, et al.
Publicado: (2015)

Involvement of NF-κBIZ and related cytokines in age-associated renal fibrosis
por: Chung, Ki Wung, et al.
Publicado: (2017)

Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes
por: Hong, Eun Shil, et al.
Publicado: (2019)

Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression
por: Song, Mi-Young, et al.
Publicado: (2022)

Management of Severe Bilateral Ptosis in a Patient With Midbrain Infarction: A Case Report
por: Kim, Soo Yeon, et al.
Publicado: (2013)

Bee Venom Inhibits Porphyromonas gingivalis Lipopolysaccharides-Induced Pro-Inflammatory Cytokines through Suppression of NF-κB and AP-1 Signaling Pathways
por: Kim, Woon-Hae, et al.
Publicado: (2016)

Age-Related Changes in Nuclear Factor Erythroid 2-Related Factor 2 and Reactive Oxygen Species and Mitochondrial Structure in the Tongues of Fischer 344 Rats
por: Baek, Min-Kwan, et al.
Publicado: (2017)

SAT031 The Effect Of Metformin On Increasing Glucose Metabolism And Secretion In The Distal Intestine
por: Ho Nam, Jung, et al.
Publicado: (2023)

Modulation of Mitochondrial Membrane Potential and ROS Generation by Nicotinamide in a Manner Independent of SIRT1 and Mitophagy
por: Song, Seon Beom, et al.
Publicado: (2017)

Lamotrigine-induced toxic epidermal necrolysis confirmed by in vitro granulysin and cytokine assays
por: Won, Ha-Kyeong, et al.
Publicado: (2014)

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
por: Knight, Colette M., et al.
Publicado: (2011)

Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells
por: Park, Jeong-A, et al.
Publicado: (2019)

Loss of Sirt6 in adipocytes impairs the ability of adipose tissue to adapt to intermittent fasting
por: Wu, Dandan, et al.
Publicado: (2021)

High power laser-driven ceramic phosphor plate for outstanding efficient white light conversion in application of automotive lighting
por: Song, Young Hyun, et al.
Publicado: (2016)

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
por: Kim, Hyun-Kyong, et al.
Publicado: (2010)

SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle
por: Koo, Young Do, et al.
Publicado: (2015)

SAT125 Promoting Habitual Exercise In People With Diabetes By Using Mission Certification Via App
por: Kim, Mi-kyung, et al.
Publicado: (2023)

Effect of gamma irradiation on mistletoe (Viscum album) lectin-mediated toxicity and immunomodulatory activity()
por: Sung, Nak-Yun, et al.
Publicado: (2013)

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
por: Khan, Salmaan Ahmed, et al.
Publicado: (2015)

Evodiae fructus Extract Inhibits Interleukin-1β-Induced MMP-1, MMP-3, and Inflammatory Cytokine Expression by Suppressing the Activation of MAPK and STAT-3 in Human Gingival Fibroblasts In Vitro
por: Song, Hyun-Kyung, et al.
Publicado: (2021)

Peroxisome Proliferator-Activated Receptor-Gamma Agonists Suppress Tissue Factor Overexpression in Rat Balloon Injury Model with Paclitaxel Infusion
por: Park, Jun-Bean, et al.
Publicado: (2011)

Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway
por: Song, Mi-Young, et al.
Publicado: (2016)

Improved Insulin Sensitivity by GLUT12 Overexpression in Mice
por: Purcell, Scott H., et al.
Publicado: (2011)

NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells
por: Shim, Ju A, et al.
Publicado: (2023)

Benign Paroxysmal Positional Vertigo with Simultaneous Involvement of Multiple Semicircular Canals
por: Shim, Dae Bo, et al.
Publicado: (2014)

Characteristics of hereditary nonpolyposis colorectal cancer patients with double primary cancers in endometrium and colorectum
por: Shin, So Hyun, et al.
Publicado: (2015)

PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners
por: Kim, Dong-Il, et al.
Publicado: (2015)

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice
por: Lantier, Louise, et al.
Publicado: (2015)

Increased Bone Mass in Mice after Single Injection of Anti-receptor Activator of Nuclear Factor-κB Ligand-neutralizing Antibody: EVIDENCE FOR BONE ANABOLIC EFFECT OF PARATHYROID HORMONE IN MICE WITH FEW OSTEOCLASTS
por: Furuya, Yuriko, et al.
Publicado: (2011)

A DNA-sensing–independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB–mediated innate immunity against DNA virus infection
por: Ng, Yee Ching, et al.
Publicado: (2018)

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance
por: Al-Share, Qusai Y., et al.
Publicado: (2015)

SAT-634 The Effect of Continine Verified Smoking on the Development of Diabetes
por: Jung, Inha, et al.
Publicado: (2020)

Subchronic oral toxicity of silver nanoparticles
por: Kim, Yong Soon, et al.
Publicado: (2010)

CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
por: Jang, Min Jun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_058kmrc7v15r14p0gkli3896a5