Glucose and Pharmacological Modulators of ATP-Sensitive K(+) Channels Control [Ca(2+)](c) by Different Mechanisms in Isolated Mouse α-Cells

OBJECTIVE—We studied how glucose and ATP-sensitive K(+) (K(ATP)) channel modulators affect α-cell [Ca(2+)](c). RESEARCH DESIGN AND METHODS—GYY mice (expressing enhanced yellow fluorescent protein in α-cells) and NMRI mice were used. [Ca(2+)](c), the K(ATP) current (I(KATP), perforated mode) and cell...

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Detalles Bibliográficos
Autores principales: Quoix, Nicolas, Cheng-Xue, Rui, Mattart, Laurine, Zeinoun, Ziad, Guiot, Yves, Beauvois, Mélanie C., Henquin, Jean-Claude, Gilon, Patrick
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628615/
https://www.ncbi.nlm.nih.gov/pubmed/19008345
http://dx.doi.org/10.2337/db07-1298

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