A Single-Nucleotide Polymorphism in a Methylatable Foxa2 Binding Site of the G6PC2 Promoter Is Associated With Insulin Secretion In Vivo and Increased Promoter Activity In Vitro

OBJECTIVE—The G6PC2 gene encoding islet-specific glucose-6-phosphatase related protein (IGRP) has a common promoter variant, rs573225 (−231G/A), located within a Foxa binding site. We tested the cis-regulatory effects of rs573225 on promoter activity and its association with insulin response to oral...

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Detalles Bibliográficos
Autores principales: Dos Santos, Christine, Bougnères, Pierre, Fradin, Delphine
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628624/
https://www.ncbi.nlm.nih.gov/pubmed/18984742
http://dx.doi.org/10.2337/db08-0587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628624/
https://www.ncbi.nlm.nih.gov/pubmed/18984742
http://dx.doi.org/10.2337/db08-0587

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