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Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy

OBJECTIVE—Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations. RESEARCH DESIGN AND METHODS—A comprehensive association analysis of 24 single-nucleotide polymorphisms (SNPs) in the...

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Autores principales: Bostrom, Meredith A., Freedman, Barry I., Langefeld, Carl D., Liu, Lingyi, Hicks, Pamela J., Bowden, Donald W.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628626/
https://www.ncbi.nlm.nih.gov/pubmed/19056609
http://dx.doi.org/10.2337/db08-0598
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author Bostrom, Meredith A.
Freedman, Barry I.
Langefeld, Carl D.
Liu, Lingyi
Hicks, Pamela J.
Bowden, Donald W.
author_facet Bostrom, Meredith A.
Freedman, Barry I.
Langefeld, Carl D.
Liu, Lingyi
Hicks, Pamela J.
Bowden, Donald W.
author_sort Bostrom, Meredith A.
collection PubMed
description OBJECTIVE—Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations. RESEARCH DESIGN AND METHODS—A comprehensive association analysis of 24 single-nucleotide polymorphisms (SNPs) in the adiponectin gene was performed for type 2 diabetes and diabetic nephropathy in African Americans. RESULTS—The minor allele (A) in a single SNP in intron 1 (rs182052) was associated with diabetic nephropathy (P = 0.0015, odds ratio [OR] 1.37, CI 1.13–1.67, dominant model) in an African American sample of 851 case subjects with diabetic nephropathy and 871 nondiabetic control subjects in analyses incorporating adjustment for varying levels of racial admixture. This association remained significant after adjustment of the data for BMI, age, and sex (P = 0.0013–0.0004). We further tested this SNP for association with longstanding type 2 diabetes without nephropathy (n = 317), and evidence of association was also significant (P = 0.0054, OR 1.46, CI 1.12–1.91, dominant model) when compared with the same set of 871 nondiabetic control subjects. Combining the type 2 diabetes and diabetic nephropathy samples into a single group of case subjects (n = 1,168) resulted in the most significant evidence of association (P = 0.0003, OR 1.40, CI 1.17–1.67, dominant model). Association tests between age at onset of type 2 diabetes and the rs182052 genotypes also revealed significant association between the presence of the minor allele (A/A or A/G) and earlier onset of type 2 diabetes. CONCLUSIONS—The SNP rs182052 in intron 1 of the adiponectin gene is associated with type 2 diabetes in African Americans.
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spelling pubmed-26286262010-02-01 Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy Bostrom, Meredith A. Freedman, Barry I. Langefeld, Carl D. Liu, Lingyi Hicks, Pamela J. Bowden, Donald W. Diabetes Genetics OBJECTIVE—Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations. RESEARCH DESIGN AND METHODS—A comprehensive association analysis of 24 single-nucleotide polymorphisms (SNPs) in the adiponectin gene was performed for type 2 diabetes and diabetic nephropathy in African Americans. RESULTS—The minor allele (A) in a single SNP in intron 1 (rs182052) was associated with diabetic nephropathy (P = 0.0015, odds ratio [OR] 1.37, CI 1.13–1.67, dominant model) in an African American sample of 851 case subjects with diabetic nephropathy and 871 nondiabetic control subjects in analyses incorporating adjustment for varying levels of racial admixture. This association remained significant after adjustment of the data for BMI, age, and sex (P = 0.0013–0.0004). We further tested this SNP for association with longstanding type 2 diabetes without nephropathy (n = 317), and evidence of association was also significant (P = 0.0054, OR 1.46, CI 1.12–1.91, dominant model) when compared with the same set of 871 nondiabetic control subjects. Combining the type 2 diabetes and diabetic nephropathy samples into a single group of case subjects (n = 1,168) resulted in the most significant evidence of association (P = 0.0003, OR 1.40, CI 1.17–1.67, dominant model). Association tests between age at onset of type 2 diabetes and the rs182052 genotypes also revealed significant association between the presence of the minor allele (A/A or A/G) and earlier onset of type 2 diabetes. CONCLUSIONS—The SNP rs182052 in intron 1 of the adiponectin gene is associated with type 2 diabetes in African Americans. American Diabetes Association 2009-02 /pmc/articles/PMC2628626/ /pubmed/19056609 http://dx.doi.org/10.2337/db08-0598 Text en Copyright © 2009, American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Genetics
Bostrom, Meredith A.
Freedman, Barry I.
Langefeld, Carl D.
Liu, Lingyi
Hicks, Pamela J.
Bowden, Donald W.
Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
title Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
title_full Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
title_fullStr Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
title_full_unstemmed Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
title_short Association of Adiponectin Gene Polymorphisms With Type 2 Diabetes in an African American Population Enriched for Nephropathy
title_sort association of adiponectin gene polymorphisms with type 2 diabetes in an african american population enriched for nephropathy
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628626/
https://www.ncbi.nlm.nih.gov/pubmed/19056609
http://dx.doi.org/10.2337/db08-0598
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