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Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study

OBJECTIVE—Markers of hemostasis and inflammation such as plasminogen activator inhibitor-1 (PAI-1) and fibrinogen have been associated with risk of type 2 diabetes. We aimed to identify food intake patterns influencing this pathway and evaluate their association with incident diabetes. RESEARCH DESI...

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Autores principales: Liese, Angela D., Weis, Kristina E., Schulz, Mandy, Tooze, Janet A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628691/
https://www.ncbi.nlm.nih.gov/pubmed/19033409
http://dx.doi.org/10.2337/dc08-1325
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author Liese, Angela D.
Weis, Kristina E.
Schulz, Mandy
Tooze, Janet A.
author_facet Liese, Angela D.
Weis, Kristina E.
Schulz, Mandy
Tooze, Janet A.
author_sort Liese, Angela D.
collection PubMed
description OBJECTIVE—Markers of hemostasis and inflammation such as plasminogen activator inhibitor-1 (PAI-1) and fibrinogen have been associated with risk of type 2 diabetes. We aimed to identify food intake patterns influencing this pathway and evaluate their association with incident diabetes. RESEARCH DESIGN AND METHODS—The Insulin Resistance Atherosclerosis Study cohort included 880 middle-aged adults initially free of diabetes. At the 5-year follow-up, 144 individuals had developed diabetes. Usual dietary intake was ascertained with a 114-item food frequency questionnaire. Using reduced rank regression, we identified a food pattern maximizing the explained variation in PAI-1 and fibrinogen. Subsequently, the food pattern–diabetes association was evaluated using logistic regression. RESULTS—High intake of the food groups red meat, low-fiber bread and cereal, dried beans, fried potatoes, tomato vegetables, eggs, cheese, and cottage cheese and low intake of wine characterized the pattern, which was positively associated with both biomarkers. With increasing pattern score, the odds of diabetes increased significantly (P(trend) < 0.01). After multivariate adjustment, the odds ratio comparing extreme quartiles was 4.3 (95% CI 1.7–10.8). Adjustment for insulin sensitivity and secretion and other metabolic factors had little impact (4.9, 1.8–13.7). CONCLUSIONS—Our findings provide support for potential behavioral prevention strategies, as we identified a food intake pattern that was strongly related to PAI-1 and fibrinogen and independently predicted type 2 diabetes.
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spelling pubmed-26286912010-02-01 Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study Liese, Angela D. Weis, Kristina E. Schulz, Mandy Tooze, Janet A. Diabetes Care Epidemiology/Health Services Research OBJECTIVE—Markers of hemostasis and inflammation such as plasminogen activator inhibitor-1 (PAI-1) and fibrinogen have been associated with risk of type 2 diabetes. We aimed to identify food intake patterns influencing this pathway and evaluate their association with incident diabetes. RESEARCH DESIGN AND METHODS—The Insulin Resistance Atherosclerosis Study cohort included 880 middle-aged adults initially free of diabetes. At the 5-year follow-up, 144 individuals had developed diabetes. Usual dietary intake was ascertained with a 114-item food frequency questionnaire. Using reduced rank regression, we identified a food pattern maximizing the explained variation in PAI-1 and fibrinogen. Subsequently, the food pattern–diabetes association was evaluated using logistic regression. RESULTS—High intake of the food groups red meat, low-fiber bread and cereal, dried beans, fried potatoes, tomato vegetables, eggs, cheese, and cottage cheese and low intake of wine characterized the pattern, which was positively associated with both biomarkers. With increasing pattern score, the odds of diabetes increased significantly (P(trend) < 0.01). After multivariate adjustment, the odds ratio comparing extreme quartiles was 4.3 (95% CI 1.7–10.8). Adjustment for insulin sensitivity and secretion and other metabolic factors had little impact (4.9, 1.8–13.7). CONCLUSIONS—Our findings provide support for potential behavioral prevention strategies, as we identified a food intake pattern that was strongly related to PAI-1 and fibrinogen and independently predicted type 2 diabetes. American Diabetes Association 2009-02 /pmc/articles/PMC2628691/ /pubmed/19033409 http://dx.doi.org/10.2337/dc08-1325 Text en Copyright © 2009, American Diabetes Association https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Epidemiology/Health Services Research
Liese, Angela D.
Weis, Kristina E.
Schulz, Mandy
Tooze, Janet A.
Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
title Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
title_full Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
title_fullStr Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
title_full_unstemmed Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
title_short Food Intake Patterns Associated With Incident Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
title_sort food intake patterns associated with incident type 2 diabetes: the insulin resistance atherosclerosis study
topic Epidemiology/Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628691/
https://www.ncbi.nlm.nih.gov/pubmed/19033409
http://dx.doi.org/10.2337/dc08-1325
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