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Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population
Vitamin D has been associated with reduced breast cancer risk. We studied the association of two vitamin D receptor (VDR) gene single nucleotide polymorphisms restriction enzyme detecting SNP of VDR (FokI and BsmI) with breast cancer risk in two independent case–control studies carried out in the sa...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Society for Endocrinology
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629179/ https://www.ncbi.nlm.nih.gov/pubmed/18719092 http://dx.doi.org/10.1677/ERC-08-0056 |
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author | Sinotte, Marc Rousseau, François Ayotte, Pierre Dewailly, Eric Diorio, Caroline Giguère, Yves Bérubé, Sylvie Brisson, Jacques |
author_facet | Sinotte, Marc Rousseau, François Ayotte, Pierre Dewailly, Eric Diorio, Caroline Giguère, Yves Bérubé, Sylvie Brisson, Jacques |
author_sort | Sinotte, Marc |
collection | PubMed |
description | Vitamin D has been associated with reduced breast cancer risk. We studied the association of two vitamin D receptor (VDR) gene single nucleotide polymorphisms restriction enzyme detecting SNP of VDR (FokI and BsmI) with breast cancer risk in two independent case–control studies carried out in the same population. The modifying effect of family history of breast cancer on this relationship was also evaluated. The first and second studies included respectively 718 (255 cases/463 controls) and 1596 (622 cases/974 controls) women recruited in Quebec City, Canada. FokI and BsmI genotypes were assessed. Relative risks of breast cancer were estimated by multivariate logistic regression. Compared with homozygotes for the common F allele (FF genotype), FokI ff homozygotes had a higher breast cancer risk (study 1: odds ratio (OR)=1.22, 95% confidence interval (CI)=0.76–1.95; study 2: OR=1.44, 95% CI=1.05–1.99; and combined studies: OR=1.33, 95% CI=1.03–1.73). Significant interactions were observed between FokI and family history of breast cancer in the two studies as well as in the combined analysis (P interaction=0.031, 0.050 and 0.0059 respectively). Among women without family history, odds ratios were 1.00, 1.27 (95% CI=1.02–1.58) and 1.57 (95% CI=1.18–2.10) respectively for FF, Ff and ff carriers (P(trend)=0.0013). BsmI Bb+bb genotypes were associated with a weak non-significant increased risk in the two studies (combined OR=1.22, 95% CI=0.95–1.57) without interaction with family history. Results support the idea that vitamin D, through its signalling pathway, can affect breast cancer risk. They also suggest that variability in observed associations between VDR FokI and breast cancer from different studies may partly be explained by the proportion of study subjects with a family history of breast cancer. |
format | Text |
id | pubmed-2629179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Society for Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-26291792009-01-28 Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population Sinotte, Marc Rousseau, François Ayotte, Pierre Dewailly, Eric Diorio, Caroline Giguère, Yves Bérubé, Sylvie Brisson, Jacques Endocr Relat Cancer Regular papers Vitamin D has been associated with reduced breast cancer risk. We studied the association of two vitamin D receptor (VDR) gene single nucleotide polymorphisms restriction enzyme detecting SNP of VDR (FokI and BsmI) with breast cancer risk in two independent case–control studies carried out in the same population. The modifying effect of family history of breast cancer on this relationship was also evaluated. The first and second studies included respectively 718 (255 cases/463 controls) and 1596 (622 cases/974 controls) women recruited in Quebec City, Canada. FokI and BsmI genotypes were assessed. Relative risks of breast cancer were estimated by multivariate logistic regression. Compared with homozygotes for the common F allele (FF genotype), FokI ff homozygotes had a higher breast cancer risk (study 1: odds ratio (OR)=1.22, 95% confidence interval (CI)=0.76–1.95; study 2: OR=1.44, 95% CI=1.05–1.99; and combined studies: OR=1.33, 95% CI=1.03–1.73). Significant interactions were observed between FokI and family history of breast cancer in the two studies as well as in the combined analysis (P interaction=0.031, 0.050 and 0.0059 respectively). Among women without family history, odds ratios were 1.00, 1.27 (95% CI=1.02–1.58) and 1.57 (95% CI=1.18–2.10) respectively for FF, Ff and ff carriers (P(trend)=0.0013). BsmI Bb+bb genotypes were associated with a weak non-significant increased risk in the two studies (combined OR=1.22, 95% CI=0.95–1.57) without interaction with family history. Results support the idea that vitamin D, through its signalling pathway, can affect breast cancer risk. They also suggest that variability in observed associations between VDR FokI and breast cancer from different studies may partly be explained by the proportion of study subjects with a family history of breast cancer. Society for Endocrinology 2008-12 /pmc/articles/PMC2629179/ /pubmed/18719092 http://dx.doi.org/10.1677/ERC-08-0056 Text en © 2008 Society for Endocrinology http://www.endocrinology.org/journals/reuselicence/ This is an Open Access article distributed under the terms of the Society for Endocrinology's Re-use Licence (http://www.endocrinology.org/journals/reuselicence/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular papers Sinotte, Marc Rousseau, François Ayotte, Pierre Dewailly, Eric Diorio, Caroline Giguère, Yves Bérubé, Sylvie Brisson, Jacques Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population |
title | Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population |
title_full | Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population |
title_fullStr | Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population |
title_full_unstemmed | Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population |
title_short | Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case–control studies within French Canadian population |
title_sort | vitamin d receptor polymorphisms (foki, bsmi) and breast cancer risk: association replication in two case–control studies within french canadian population |
topic | Regular papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629179/ https://www.ncbi.nlm.nih.gov/pubmed/18719092 http://dx.doi.org/10.1677/ERC-08-0056 |
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