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MDM2 is a novel E3 ligase for HIV-1 Vif

The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G). Vif interacts with A3G and induces its polyubiquitination and subsequent degradation via the formation of active ubiquitin ligase (E3) complex wi...

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Detalles Bibliográficos
Autores principales:	Izumi, Taisuke, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Higashitsuji, Hiroaki, Itoh, Katsuhiko, Io, Katsuhiro, Matsui, Masashi, Iwai, Kazuhiro, Kondoh, Hiroshi, Sato, Toshihiro, Tomonaga, Mitsunori, Ikeda, Satoru, Akari, Hirofumi, Koyanagi, Yoshio, Fujita, Jun, Uchiyama, Takashi
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2009
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629459/ https://www.ncbi.nlm.nih.gov/pubmed/19128510 http://dx.doi.org/10.1186/1742-4690-6-1

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