Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

BACKGROUND: Recently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling. In the present study we explored the specificity of these receptors and we analyzed downstream effectors controlling survival and apoptosis i...

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Detalles Bibliográficos
Autores principales: Papadopoulou, Natalia, Charalampopoulos, Ioannis, Anagnostopoulou, Vasileia, Konstantinidis, Georgios, Föller, Michael, Gravanis, Achilleas, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629475/
https://www.ncbi.nlm.nih.gov/pubmed/19055752
http://dx.doi.org/10.1186/1476-4598-7-88

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