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Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report
INTRODUCTION: Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneu...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629480/ https://www.ncbi.nlm.nih.gov/pubmed/19055816 http://dx.doi.org/10.1186/1752-1947-2-370 |
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author | Sloan, Derek J Nicolson, Andrew Miller, Alastair RO Beeching, Nick J Beadsworth, Mike BJ |
author_facet | Sloan, Derek J Nicolson, Andrew Miller, Alastair RO Beeching, Nick J Beadsworth, Mike BJ |
author_sort | Sloan, Derek J |
collection | PubMed |
description | INTRODUCTION: Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneuropathy has occasionally been reported in acute Immunodeficiency Virus infection but little data exists on frequency, management and outcome. CASE PRESENTATION: We describe an episode of Guillain-Barré syndrome presenting as acute inflammatory demyelinating polyneuropathy in a 30-year-old man testing positive for Immunodeficiency Virus, probably during acute seroconversion. Clinical suspicion was confirmed by cerebrospinal fluid analysis and nerve conduction studies. Rapid clinical deterioration prompted intravenous immunoglobulin therapy and early commencement of highly active anti-retroviral therapy. All symptoms resolved within nine weeks. CONCLUSION: Unusual neurological presentations in previously fit patients are an appropriate indication for Immunodeficiency-Virus testing. Highly active anti-retroviral therapy with adequate penetration of the central nervous system should be considered as an early intervention, alongside conventional therapies such as intravenous immunoglobulin. |
format | Text |
id | pubmed-2629480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26294802009-01-22 Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report Sloan, Derek J Nicolson, Andrew Miller, Alastair RO Beeching, Nick J Beadsworth, Mike BJ J Med Case Reports Case Report INTRODUCTION: Acute Human Immunodeficiency Virus infection is associated with a range of neurological conditions. Guillain-Barré syndrome is a rare presentation; acute inflammatory demyelinating polyneuropathy is the commonest form of Guillain-Barré syndrome. Acute inflammatory demyelinating polyneuropathy has occasionally been reported in acute Immunodeficiency Virus infection but little data exists on frequency, management and outcome. CASE PRESENTATION: We describe an episode of Guillain-Barré syndrome presenting as acute inflammatory demyelinating polyneuropathy in a 30-year-old man testing positive for Immunodeficiency Virus, probably during acute seroconversion. Clinical suspicion was confirmed by cerebrospinal fluid analysis and nerve conduction studies. Rapid clinical deterioration prompted intravenous immunoglobulin therapy and early commencement of highly active anti-retroviral therapy. All symptoms resolved within nine weeks. CONCLUSION: Unusual neurological presentations in previously fit patients are an appropriate indication for Immunodeficiency-Virus testing. Highly active anti-retroviral therapy with adequate penetration of the central nervous system should be considered as an early intervention, alongside conventional therapies such as intravenous immunoglobulin. BioMed Central 2008-12-04 /pmc/articles/PMC2629480/ /pubmed/19055816 http://dx.doi.org/10.1186/1752-1947-2-370 Text en Copyright © 2008 Sloan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sloan, Derek J Nicolson, Andrew Miller, Alastair RO Beeching, Nick J Beadsworth, Mike BJ Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
title | Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
title_full | Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
title_fullStr | Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
title_full_unstemmed | Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
title_short | Human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
title_sort | human immunodeficiency virus seroconversion presenting with acute inflammatory demyelinating polyneuropathy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629480/ https://www.ncbi.nlm.nih.gov/pubmed/19055816 http://dx.doi.org/10.1186/1752-1947-2-370 |
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