Cargando…
Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death
BACKGROUND: Neonatal death in full-term infants who suffer from perinatal asphyxia (PA) is a major subject of investigation, since few tools exist to predict patients at risk of ominous outcome. We studied the possibility that urine S100B measurement may identify which PA-affected infants are at ris...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629535/ https://www.ncbi.nlm.nih.gov/pubmed/19183802 http://dx.doi.org/10.1371/journal.pone.0004298 |
_version_ | 1782163786918002688 |
---|---|
author | Gazzolo, Diego Frigiola, Alessandro Bashir, Moataza Iskander, Iman Mufeed, Hala Aboulgar, Hanna Venturini, Pierluigi Marras, Mauro Serra, Giovanni Frulio, Rosanna Michetti, Fabrizio Petraglia, Felice Abella, Raul Florio, Pasquale |
author_facet | Gazzolo, Diego Frigiola, Alessandro Bashir, Moataza Iskander, Iman Mufeed, Hala Aboulgar, Hanna Venturini, Pierluigi Marras, Mauro Serra, Giovanni Frulio, Rosanna Michetti, Fabrizio Petraglia, Felice Abella, Raul Florio, Pasquale |
author_sort | Gazzolo, Diego |
collection | PubMed |
description | BACKGROUND: Neonatal death in full-term infants who suffer from perinatal asphyxia (PA) is a major subject of investigation, since few tools exist to predict patients at risk of ominous outcome. We studied the possibility that urine S100B measurement may identify which PA-affected infants are at risk of early postnatal death. METHODOLOGY/PRINCIPAL FINDINGS: In a cross-sectional study between January 1, 2001 and December 1, 2006 we measured S100B protein in urine collected from term infants (n = 132), 60 of whom suffered PA. According to their outcome at 7 days, infants with PA were subsequently classified either as asphyxiated infants complicated by hypoxic ischemic encephalopathy with no ominous outcome (HIE Group; n = 48), or as newborns who died within the first post-natal week (Ominous Outcome Group; n = 12). Routine laboratory variables, cerebral ultrasound, neurological patterns and urine concentrations of S100B protein were determined at first urination and after 24, 48 and 96 hours. The severity of illness in the first 24 hours after birth was measured using the Score for Neonatal Acute Physiology-Perinatal Extension (SNAP-PE). Urine S100B levels were higher from the first urination in the ominous outcome group than in healthy or HIE Groups (p<0.001 for all), and progressively increased. Multiple logistic regression analysis showed a significant correlation between S100B concentrations and the occurrence of neonatal death. At a cut-off >1.0 µg/L S100B had a sensitivity/specificity of 100% for predicting neonatal death. CONCLUSIONS/SIGNIFICANCE: Increased S100B protein urine levels in term newborns suffering PA seem to suggest a higher risk of neonatal death for these infants. |
format | Text |
id | pubmed-2629535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-26295352009-02-02 Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death Gazzolo, Diego Frigiola, Alessandro Bashir, Moataza Iskander, Iman Mufeed, Hala Aboulgar, Hanna Venturini, Pierluigi Marras, Mauro Serra, Giovanni Frulio, Rosanna Michetti, Fabrizio Petraglia, Felice Abella, Raul Florio, Pasquale PLoS One Research Article BACKGROUND: Neonatal death in full-term infants who suffer from perinatal asphyxia (PA) is a major subject of investigation, since few tools exist to predict patients at risk of ominous outcome. We studied the possibility that urine S100B measurement may identify which PA-affected infants are at risk of early postnatal death. METHODOLOGY/PRINCIPAL FINDINGS: In a cross-sectional study between January 1, 2001 and December 1, 2006 we measured S100B protein in urine collected from term infants (n = 132), 60 of whom suffered PA. According to their outcome at 7 days, infants with PA were subsequently classified either as asphyxiated infants complicated by hypoxic ischemic encephalopathy with no ominous outcome (HIE Group; n = 48), or as newborns who died within the first post-natal week (Ominous Outcome Group; n = 12). Routine laboratory variables, cerebral ultrasound, neurological patterns and urine concentrations of S100B protein were determined at first urination and after 24, 48 and 96 hours. The severity of illness in the first 24 hours after birth was measured using the Score for Neonatal Acute Physiology-Perinatal Extension (SNAP-PE). Urine S100B levels were higher from the first urination in the ominous outcome group than in healthy or HIE Groups (p<0.001 for all), and progressively increased. Multiple logistic regression analysis showed a significant correlation between S100B concentrations and the occurrence of neonatal death. At a cut-off >1.0 µg/L S100B had a sensitivity/specificity of 100% for predicting neonatal death. CONCLUSIONS/SIGNIFICANCE: Increased S100B protein urine levels in term newborns suffering PA seem to suggest a higher risk of neonatal death for these infants. Public Library of Science 2009-02-02 /pmc/articles/PMC2629535/ /pubmed/19183802 http://dx.doi.org/10.1371/journal.pone.0004298 Text en Gazzolo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Gazzolo, Diego Frigiola, Alessandro Bashir, Moataza Iskander, Iman Mufeed, Hala Aboulgar, Hanna Venturini, Pierluigi Marras, Mauro Serra, Giovanni Frulio, Rosanna Michetti, Fabrizio Petraglia, Felice Abella, Raul Florio, Pasquale Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death |
title | Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death |
title_full | Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death |
title_fullStr | Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death |
title_full_unstemmed | Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death |
title_short | Diagnostic Accuracy of S100B Urinary Testing at Birth in Full-Term Asphyxiated Newborns to Predict Neonatal Death |
title_sort | diagnostic accuracy of s100b urinary testing at birth in full-term asphyxiated newborns to predict neonatal death |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629535/ https://www.ncbi.nlm.nih.gov/pubmed/19183802 http://dx.doi.org/10.1371/journal.pone.0004298 |
work_keys_str_mv | AT gazzolodiego diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT frigiolaalessandro diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT bashirmoataza diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT iskanderiman diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT mufeedhala diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT aboulgarhanna diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT venturinipierluigi diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT marrasmauro diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT serragiovanni diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT fruliorosanna diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT michettifabrizio diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT petragliafelice diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT abellaraul diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath AT floriopasquale diagnosticaccuracyofs100burinarytestingatbirthinfulltermasphyxiatednewbornstopredictneonataldeath |