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Sequential Metabolism of 7-Dehydrocholesterol to Steroidal 5,7-Dienes in Adrenal Glands and Its Biological Implication in the Skin

Since P450scc transforms 7-dehydrocholesterol (7DHC) to 7-dehydropregnenolone (7DHP) in vitro, we investigated sequential 7DHC metabolism by adrenal glands ex vivo. There was a rapid, time- and dose-dependent metabolism of 7DHC by adrenals from rats, pigs, rabbits and dogs with production of more po...

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Detalles Bibliográficos
Autores principales:	Slominski, Andrzej T., Zmijewski, Michal A., Semak, Igor, Sweatman, Trevor, Janjetovic, Zorica, Li, Wei, Zjawiony, Jordan K., Tuckey, Robert C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629546/ https://www.ncbi.nlm.nih.gov/pubmed/19190754 http://dx.doi.org/10.1371/journal.pone.0004309

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