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Adaptive Mutations in the JC Virus Protein Capsid Are Associated with Progressive Multifocal Leukoencephalopathy (PML)

PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals. While JC virus is highly prevalent in the human population, PML is a rare disease that exclusively afflicts only a...

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Detalles Bibliográficos
Autores principales:	Sunyaev, Shamil R., Lugovskoy, Alexey, Simon, Kenneth, Gorelik, Leonid
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629573/ https://www.ncbi.nlm.nih.gov/pubmed/19197354 http://dx.doi.org/10.1371/journal.pgen.1000368

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