Expression of Activated PIK3CA in Ovarian Surface Epithelium Results in Hyperplasia but Not Tumor Formation

BACKGROUND: The Phosphatidylinositol 3′-kinase is a key regulator in various cancer-associated signal transduction pathways. Genetic alterations of its catalytic subunit alpha, PIK3CA, have been identified in ovarian cancer. Our in vivo data suggests that PIK3CA activation is one of the early geneti...

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Detalles Bibliográficos
Autores principales: Liang, Shun, Yang, Nuo, Pan, Yue, Deng, Shan, Lin, Xiaojuan, Yang, Xiaojun, Katsaros, Dionyssios, Roby, Katherine F., Hamilton, Thomas C., Connolly, Denise C., Coukos, George, Zhang, Lin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629728/
https://www.ncbi.nlm.nih.gov/pubmed/19172191
http://dx.doi.org/10.1371/journal.pone.0004295

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