Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells

Ubiquitously acting chromatin opening elements (UCOEs) consist of methylation-free CpG islands encompassing dual divergently transcribed promoters of housekeeping genes that have been shown to confer resistance to transcriptional silencing and to produce consistent and stable transgene expression in...

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Detalles Bibliográficos
Autores principales: Zhang, Fang, Thornhill, Susannah I., Howe, Steven J., Ulaganathan, Meera, Schambach, Axel, Sinclair, Joanna, Kinnon, Christine, Gaspar, H. Bobby, Antoniou, Michael, Thrasher, Adrian J.
Formato: Texto
Lenguaje:English
Publicado: American Society of Hematology 2007
Materias:
Gene Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629730/
https://www.ncbi.nlm.nih.gov/pubmed/17456723
http://dx.doi.org/10.1182/blood-2006-12-060814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629730/
https://www.ncbi.nlm.nih.gov/pubmed/17456723
http://dx.doi.org/10.1182/blood-2006-12-060814

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