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Crystal Structure of a p53 Core Tetramer Bound to DNA

The tumor suppressor p53 regulates downstream genes in response to many cellular stresses and is frequently mutated in human cancers. Here, we report the use of a crosslinking strategy to trap a tetrameric p53 DNA binding domain (p53DBD) bound to DNA and the X-ray crystal structure of the protein/DN...

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Detalles Bibliográficos
Autores principales:	Malecka, Kimberly A., Ho, William C., Marmorstein, Ronen
Formato:	Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629805/ https://www.ncbi.nlm.nih.gov/pubmed/18978813 http://dx.doi.org/10.1038/onc.2008.400

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