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Gene-environment interactions in chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death throughout the world and is largely associated with cigarette smoking. Despite the appreciation of the central role of smoking in the development of COPD, only a relatively small number of smokers (15%–20%) develop CO...

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Detalles Bibliográficos
Autores principales: Molfino, Nestor A, Coyle, Anthony J
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629985/
https://www.ncbi.nlm.nih.gov/pubmed/18990979
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author Molfino, Nestor A
Coyle, Anthony J
author_facet Molfino, Nestor A
Coyle, Anthony J
author_sort Molfino, Nestor A
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death throughout the world and is largely associated with cigarette smoking. Despite the appreciation of the central role of smoking in the development of COPD, only a relatively small number of smokers (15%–20%) develop COPD. Recent studies depicting familial aggregation suggest that some subjects may have a genetic predisposition to developing COPD. In this respect, a number of single nucleotide polymorphisms have been reported in association with different COPD features (subphenotypes), although much of this data remains controversial. Classical genetic studies (including twin and family studies) assume an “equal-environment” scenario, but as gene-environment interactions occur in COPD, this assumption needs revision. Thus, new integrated models are needed to examine the major environmental factors associated with COPD which include smoking as well as air pollution, and respiratory infections, and not only genetic predisposition. Revisiting this area, may help answer the question of what has more bearing in the pathogenesis of COPD—the environment or the genomic sequence of the affected subjects. It is anticipated that an improved understanding of this interaction will both enable improved identification of individuals susceptible to developing this disease, as well as improved future treatments for this disease.
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spelling pubmed-26299852009-05-04 Gene-environment interactions in chronic obstructive pulmonary disease Molfino, Nestor A Coyle, Anthony J Int J Chron Obstruct Pulmon Dis Commentary Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death throughout the world and is largely associated with cigarette smoking. Despite the appreciation of the central role of smoking in the development of COPD, only a relatively small number of smokers (15%–20%) develop COPD. Recent studies depicting familial aggregation suggest that some subjects may have a genetic predisposition to developing COPD. In this respect, a number of single nucleotide polymorphisms have been reported in association with different COPD features (subphenotypes), although much of this data remains controversial. Classical genetic studies (including twin and family studies) assume an “equal-environment” scenario, but as gene-environment interactions occur in COPD, this assumption needs revision. Thus, new integrated models are needed to examine the major environmental factors associated with COPD which include smoking as well as air pollution, and respiratory infections, and not only genetic predisposition. Revisiting this area, may help answer the question of what has more bearing in the pathogenesis of COPD—the environment or the genomic sequence of the affected subjects. It is anticipated that an improved understanding of this interaction will both enable improved identification of individuals susceptible to developing this disease, as well as improved future treatments for this disease. Dove Medical Press 2008-09 2008-09 /pmc/articles/PMC2629985/ /pubmed/18990979 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Commentary
Molfino, Nestor A
Coyle, Anthony J
Gene-environment interactions in chronic obstructive pulmonary disease
title Gene-environment interactions in chronic obstructive pulmonary disease
title_full Gene-environment interactions in chronic obstructive pulmonary disease
title_fullStr Gene-environment interactions in chronic obstructive pulmonary disease
title_full_unstemmed Gene-environment interactions in chronic obstructive pulmonary disease
title_short Gene-environment interactions in chronic obstructive pulmonary disease
title_sort gene-environment interactions in chronic obstructive pulmonary disease
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629985/
https://www.ncbi.nlm.nih.gov/pubmed/18990979
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