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Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend

BACKGROUND: Transcriptional regulatory elements are central to development and interspecific phenotypic variation. Current regulatory element prediction tools rely heavily upon conservation for prediction of putative elements. Recent in vitro observations from the ENCODE project combined with in viv...

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Detalles Bibliográficos
Autores principales: McGaughey, David M, Stine, Zachary E, Huynh, Jimmy L, Vinton, Ryan M, McCallion, Andrew S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630312/
https://www.ncbi.nlm.nih.gov/pubmed/19128492
http://dx.doi.org/10.1186/1471-2164-10-8