Learning about protein solubility from bacterial inclusion bodies

The progressive solving of the conformation of aggregated proteins and the conceptual understanding of the biology of inclusion bodies in recombinant bacteria is providing exciting insights on protein folding and quality. Interestingly, newest data also show an unexpected functional and structural c...

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Detalles Bibliográficos
Autores principales: Martínez-Alonso, Mónica, González-Montalbán, Nuria, García-Fruitós, Elena, Villaverde, Antonio
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630952/
https://www.ncbi.nlm.nih.gov/pubmed/19133126
http://dx.doi.org/10.1186/1475-2859-8-4
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author Martínez-Alonso, Mónica
González-Montalbán, Nuria
García-Fruitós, Elena
Villaverde, Antonio
author_facet Martínez-Alonso, Mónica
González-Montalbán, Nuria
García-Fruitós, Elena
Villaverde, Antonio
author_sort Martínez-Alonso, Mónica
collection PubMed
description The progressive solving of the conformation of aggregated proteins and the conceptual understanding of the biology of inclusion bodies in recombinant bacteria is providing exciting insights on protein folding and quality. Interestingly, newest data also show an unexpected functional and structural complexity of soluble recombinant protein species and picture the whole bacterial cell factory scenario as more intricate than formerly believed.
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spelling pubmed-26309522009-01-27 Learning about protein solubility from bacterial inclusion bodies Martínez-Alonso, Mónica González-Montalbán, Nuria García-Fruitós, Elena Villaverde, Antonio Microb Cell Fact Commentary The progressive solving of the conformation of aggregated proteins and the conceptual understanding of the biology of inclusion bodies in recombinant bacteria is providing exciting insights on protein folding and quality. Interestingly, newest data also show an unexpected functional and structural complexity of soluble recombinant protein species and picture the whole bacterial cell factory scenario as more intricate than formerly believed. BioMed Central 2009-01-08 /pmc/articles/PMC2630952/ /pubmed/19133126 http://dx.doi.org/10.1186/1475-2859-8-4 Text en Copyright © 2009 Martínez-Alonso et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Martínez-Alonso, Mónica
González-Montalbán, Nuria
García-Fruitós, Elena
Villaverde, Antonio
Learning about protein solubility from bacterial inclusion bodies
title Learning about protein solubility from bacterial inclusion bodies
title_full Learning about protein solubility from bacterial inclusion bodies
title_fullStr Learning about protein solubility from bacterial inclusion bodies
title_full_unstemmed Learning about protein solubility from bacterial inclusion bodies
title_short Learning about protein solubility from bacterial inclusion bodies
title_sort learning about protein solubility from bacterial inclusion bodies
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630952/
https://www.ncbi.nlm.nih.gov/pubmed/19133126
http://dx.doi.org/10.1186/1475-2859-8-4
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