NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1...

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Detalles Bibliográficos
Autores principales: Bradshaw, Nicholas J., Christie, Sheila, Soares, Dinesh C., Carlyle, Becky C., Porteous, David J., Millar, J. Kirsty
Formato: Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631193/
https://www.ncbi.nlm.nih.gov/pubmed/19000741
http://dx.doi.org/10.1016/j.neulet.2008.10.095
Descripción
Sumario:Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself. We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity of DISC1-mediated regulation of neuronal activity.

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