NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction

Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1...

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Detalles Bibliográficos
Autores principales: Bradshaw, Nicholas J., Christie, Sheila, Soares, Dinesh C., Carlyle, Becky C., Porteous, David J., Millar, J. Kirsty
Formato: Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers Ireland 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631193/
https://www.ncbi.nlm.nih.gov/pubmed/19000741
http://dx.doi.org/10.1016/j.neulet.2008.10.095
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author Bradshaw, Nicholas J.
Christie, Sheila
Soares, Dinesh C.
Carlyle, Becky C.
Porteous, David J.
Millar, J. Kirsty
author_facet Bradshaw, Nicholas J.
Christie, Sheila
Soares, Dinesh C.
Carlyle, Becky C.
Porteous, David J.
Millar, J. Kirsty
author_sort Bradshaw, Nicholas J.
collection PubMed
description Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself. We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity of DISC1-mediated regulation of neuronal activity.
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spelling pubmed-26311932009-01-30 NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction Bradshaw, Nicholas J. Christie, Sheila Soares, Dinesh C. Carlyle, Becky C. Porteous, David J. Millar, J. Kirsty Neurosci Lett Article Nuclear Distribution Factor E Homolog 1 (NDE1) and NDE-Like 1 (NDEL1) are highly homologous mammalian proteins. However, whereas NDEL1 is well studied, there is remarkably little known about NDE1. We demonstrate the presence of multiple isoforms of both NDE1 and NDEL1 in the brain, showing that NDE1 binds directly to multiple isoforms of Disrupted in Schizophrenia 1 (DISC1), and to itself. We also show that NDE1 can complex with NDEL1. Together these results predict a high degree of complexity of DISC1-mediated regulation of neuronal activity. Elsevier Scientific Publishers Ireland 2009-01-16 /pmc/articles/PMC2631193/ /pubmed/19000741 http://dx.doi.org/10.1016/j.neulet.2008.10.095 Text en © 2009 Elsevier Ireland Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
Bradshaw, Nicholas J.
Christie, Sheila
Soares, Dinesh C.
Carlyle, Becky C.
Porteous, David J.
Millar, J. Kirsty
NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
title NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
title_full NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
title_fullStr NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
title_full_unstemmed NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
title_short NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction
title_sort nde1 and ndel1: multimerisation, alternate splicing and disc1 interaction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631193/
https://www.ncbi.nlm.nih.gov/pubmed/19000741
http://dx.doi.org/10.1016/j.neulet.2008.10.095
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