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Depression and body mass index, a u-shaped association
BACKGROUND: Results of studies concerning the association between obesity and depression are conflicting. Some find a positive association, some a negative association and some find no association at all. Most studies, however, examine a linear association between Body Mass Index (BMI) and depressio...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631467/ https://www.ncbi.nlm.nih.gov/pubmed/19144098 http://dx.doi.org/10.1186/1471-2458-9-14 |
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author | de Wit, Leonore M van Straten, Annemieke van Herten, Marieke Penninx, Brenda WJH Cuijpers, Pim |
author_facet | de Wit, Leonore M van Straten, Annemieke van Herten, Marieke Penninx, Brenda WJH Cuijpers, Pim |
author_sort | de Wit, Leonore M |
collection | PubMed |
description | BACKGROUND: Results of studies concerning the association between obesity and depression are conflicting. Some find a positive association, some a negative association and some find no association at all. Most studies, however, examine a linear association between Body Mass Index (BMI) and depression. The present study investigates if a nonlinear (U-shaped) trend is preferable over a linear trend to describe the relationship between BMI and depression, which means that both underweight and obesity are associated with depression. METHODS: We investigated the existence of such a U-curve in a sample of 43,534 individuals, aged between 18–90 years, who participated in a cross-sectional study (Continuous Survey of Living Conditions) of physical and mental health in the general population of the Netherlands. We calculated linear and nonlinear (quadratic) ANOVA with polynomial contrast and curve fit regression statistics to investigate whether there was a U-shaped trend in the association between BMI and depression. RESULTS: We find a very significant U-shaped association between BMI categories (underweight, normal, overweight and obesity) and depression (p ≤ 0.001). There is a trend indicating a significant difference in the association between males and females (p = 0.05). We find a very significant U-shaped (quadratic) association between BMI (BMI(2)) and depression (p ≤ 0.001), continuous BMI is not linearly associated with depression (p = 0.514). CONCLUSION: The results of this study give evidence for a significant U-shaped trend in the association between BMI and depression. |
format | Text |
id | pubmed-2631467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-26314672009-01-28 Depression and body mass index, a u-shaped association de Wit, Leonore M van Straten, Annemieke van Herten, Marieke Penninx, Brenda WJH Cuijpers, Pim BMC Public Health Research Article BACKGROUND: Results of studies concerning the association between obesity and depression are conflicting. Some find a positive association, some a negative association and some find no association at all. Most studies, however, examine a linear association between Body Mass Index (BMI) and depression. The present study investigates if a nonlinear (U-shaped) trend is preferable over a linear trend to describe the relationship between BMI and depression, which means that both underweight and obesity are associated with depression. METHODS: We investigated the existence of such a U-curve in a sample of 43,534 individuals, aged between 18–90 years, who participated in a cross-sectional study (Continuous Survey of Living Conditions) of physical and mental health in the general population of the Netherlands. We calculated linear and nonlinear (quadratic) ANOVA with polynomial contrast and curve fit regression statistics to investigate whether there was a U-shaped trend in the association between BMI and depression. RESULTS: We find a very significant U-shaped association between BMI categories (underweight, normal, overweight and obesity) and depression (p ≤ 0.001). There is a trend indicating a significant difference in the association between males and females (p = 0.05). We find a very significant U-shaped (quadratic) association between BMI (BMI(2)) and depression (p ≤ 0.001), continuous BMI is not linearly associated with depression (p = 0.514). CONCLUSION: The results of this study give evidence for a significant U-shaped trend in the association between BMI and depression. BioMed Central 2009-01-13 /pmc/articles/PMC2631467/ /pubmed/19144098 http://dx.doi.org/10.1186/1471-2458-9-14 Text en Copyright © 2009 de Wit et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article de Wit, Leonore M van Straten, Annemieke van Herten, Marieke Penninx, Brenda WJH Cuijpers, Pim Depression and body mass index, a u-shaped association |
title | Depression and body mass index, a u-shaped association |
title_full | Depression and body mass index, a u-shaped association |
title_fullStr | Depression and body mass index, a u-shaped association |
title_full_unstemmed | Depression and body mass index, a u-shaped association |
title_short | Depression and body mass index, a u-shaped association |
title_sort | depression and body mass index, a u-shaped association |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631467/ https://www.ncbi.nlm.nih.gov/pubmed/19144098 http://dx.doi.org/10.1186/1471-2458-9-14 |
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