Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo

BACKGROUND: Cells derived from native rodents have limits at distinct steps of HIV replication. Rat primary CD4 T-cells, but not macrophages, display a profound transcriptional deficit that is ameliorated by transient trans-complementation with the human Tat-interacting protein Cyclin T1 (hCycT1). R...

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Detalles Bibliográficos
Autores principales: Michel, Nico, Goffinet, Christine, Ganter, Kerstin, Allespach, Ina, KewalRamani, Vineet N, Saifuddin, Mohammed, Littman, Dan R, Greene, Warner C, Goldsmith, Mark A, Keppler, Oliver T
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631513/
https://www.ncbi.nlm.nih.gov/pubmed/19144136
http://dx.doi.org/10.1186/1742-4690-6-2

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