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The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer

BACKGROUND: The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. Whereas it is known that c-myc alterations play a completely different r...

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Autores principales: Weber, Achim, Kristiansen, Ilka, Johannsen, Manfred, Oelrich, Beibei, Scholmann, Katharina, Gunia, Sven, May, Matthias, Meyer, Hellmuth-Alexander, Behnke, Silvia, Moch, Holger, Kristiansen, Glen
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631590/
https://www.ncbi.nlm.nih.gov/pubmed/19087307
http://dx.doi.org/10.1186/1471-2407-8-369
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author Weber, Achim
Kristiansen, Ilka
Johannsen, Manfred
Oelrich, Beibei
Scholmann, Katharina
Gunia, Sven
May, Matthias
Meyer, Hellmuth-Alexander
Behnke, Silvia
Moch, Holger
Kristiansen, Glen
author_facet Weber, Achim
Kristiansen, Ilka
Johannsen, Manfred
Oelrich, Beibei
Scholmann, Katharina
Gunia, Sven
May, Matthias
Meyer, Hellmuth-Alexander
Behnke, Silvia
Moch, Holger
Kristiansen, Glen
author_sort Weber, Achim
collection PubMed
description BACKGROUND: The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. Whereas it is known that c-myc alterations play a completely different role in various carcinomas of the urogenital tract, the relevance of FBPs is unclear. METHODS: FBP1, FBP3 and c-myc expression was studied in 105 renal cell, 95 prostate and 112 urinary bladder carcinomas by immunohistochemistry using tissue microarrays. RESULTS: High rates of FBP1 and FBP3 expression were observed in all cancer types. There was a concomitant up-regulation of FBP1 and FBP3 in renal cell and prostate carcinomas (p < 0.001 both). C-myc expression was detectable in 21% of prostate, 30% of renal and 34% of urothelial carcinomas. Interestingly, strong FBP1 and FBP3 expression was associated with c-myc up-regulation in clear cell renal cell carcinomas (p < 0.001 and 0.09 resp.), but not in bladder or prostate cancer. CONCLUSION: The correlation between FBP1/FBP3, c-myc and high proliferation rate in renal cell carcinoma provides strong in vivo support for the suggested role of FBP1 and FBP3 as activators of c-myc. The frequent up-regulation of FBP1 and FBP3 in urothelial and prostate carcinoma suggests that FBPs also have an important function in gene regulation of these tumors.
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spelling pubmed-26315902009-01-28 The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer Weber, Achim Kristiansen, Ilka Johannsen, Manfred Oelrich, Beibei Scholmann, Katharina Gunia, Sven May, Matthias Meyer, Hellmuth-Alexander Behnke, Silvia Moch, Holger Kristiansen, Glen BMC Cancer Research Article BACKGROUND: The three far-upstream element (FUSE) binding proteins (FBP1, FBP2, and FBP3) belong to an ancient family of single-stranded DNA binding proteins which are required for proper regulation of the c-myc proto-oncogene. Whereas it is known that c-myc alterations play a completely different role in various carcinomas of the urogenital tract, the relevance of FBPs is unclear. METHODS: FBP1, FBP3 and c-myc expression was studied in 105 renal cell, 95 prostate and 112 urinary bladder carcinomas by immunohistochemistry using tissue microarrays. RESULTS: High rates of FBP1 and FBP3 expression were observed in all cancer types. There was a concomitant up-regulation of FBP1 and FBP3 in renal cell and prostate carcinomas (p < 0.001 both). C-myc expression was detectable in 21% of prostate, 30% of renal and 34% of urothelial carcinomas. Interestingly, strong FBP1 and FBP3 expression was associated with c-myc up-regulation in clear cell renal cell carcinomas (p < 0.001 and 0.09 resp.), but not in bladder or prostate cancer. CONCLUSION: The correlation between FBP1/FBP3, c-myc and high proliferation rate in renal cell carcinoma provides strong in vivo support for the suggested role of FBP1 and FBP3 as activators of c-myc. The frequent up-regulation of FBP1 and FBP3 in urothelial and prostate carcinoma suggests that FBPs also have an important function in gene regulation of these tumors. BioMed Central 2008-12-16 /pmc/articles/PMC2631590/ /pubmed/19087307 http://dx.doi.org/10.1186/1471-2407-8-369 Text en Copyright © 2008 Weber et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Weber, Achim
Kristiansen, Ilka
Johannsen, Manfred
Oelrich, Beibei
Scholmann, Katharina
Gunia, Sven
May, Matthias
Meyer, Hellmuth-Alexander
Behnke, Silvia
Moch, Holger
Kristiansen, Glen
The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
title The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
title_full The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
title_fullStr The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
title_full_unstemmed The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
title_short The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
title_sort fuse binding proteins fbp1 and fbp3 are potential c-myc regulators in renal, but not in prostate and bladder cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631590/
https://www.ncbi.nlm.nih.gov/pubmed/19087307
http://dx.doi.org/10.1186/1471-2407-8-369
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