Cargando…

Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.

Strains of Staphylococcus aureus with reduced susceptibility to glycopeptides have been reported from Japan, the United States, Europe, and the Far East. Although isolates with homogeneous resistance to vancomycin (MICs = 8 microg/mL) continue to be rare, there are increasing reports of strains show...

Descripción completa

Detalles Bibliográficos
Autores principales: Tenover, F C, Biddle, J W, Lancaster, M V
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631729/
https://www.ncbi.nlm.nih.gov/pubmed/11294734
_version_ 1782163971614179328
author Tenover, F C
Biddle, J W
Lancaster, M V
author_facet Tenover, F C
Biddle, J W
Lancaster, M V
author_sort Tenover, F C
collection PubMed
description Strains of Staphylococcus aureus with reduced susceptibility to glycopeptides have been reported from Japan, the United States, Europe, and the Far East. Although isolates with homogeneous resistance to vancomycin (MICs = 8 microg/mL) continue to be rare, there are increasing reports of strains showing heteroresistance, often with vancomycin MICs in the 1-4 microg/mL range. Most isolates with reduced susceptibility to vancomycin appear to have developed from preexisting methicillin-resistant S. aureus infections. Many of the isolates with reduced susceptibility to glycopeptides have been associated with therapeutic failures with vancomycin. Although nosocomial spread of the vancomycin-intermediate S. aureus (VISA) strains has not been observed in U.S. hospitals, spread of VISA strains has apparently occurred in Japan. Broth microdilution tests held a full 24 hours are optimal for detecting resistance in the laboratory; however, methods for detecting heteroresistant strains are still in flux. Disk-diffusion tests, including the Stokes method, do not detect VISA strains. The Centers for Disease Control and Prevention and other groups have issued recommendations regarding appropriate infection control procedures for patients infected with these strains.
format Text
id pubmed-2631729
institution National Center for Biotechnology Information
language English
publishDate 2001
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-26317292009-05-20 Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus. Tenover, F C Biddle, J W Lancaster, M V Emerg Infect Dis Research Article Strains of Staphylococcus aureus with reduced susceptibility to glycopeptides have been reported from Japan, the United States, Europe, and the Far East. Although isolates with homogeneous resistance to vancomycin (MICs = 8 microg/mL) continue to be rare, there are increasing reports of strains showing heteroresistance, often with vancomycin MICs in the 1-4 microg/mL range. Most isolates with reduced susceptibility to vancomycin appear to have developed from preexisting methicillin-resistant S. aureus infections. Many of the isolates with reduced susceptibility to glycopeptides have been associated with therapeutic failures with vancomycin. Although nosocomial spread of the vancomycin-intermediate S. aureus (VISA) strains has not been observed in U.S. hospitals, spread of VISA strains has apparently occurred in Japan. Broth microdilution tests held a full 24 hours are optimal for detecting resistance in the laboratory; however, methods for detecting heteroresistant strains are still in flux. Disk-diffusion tests, including the Stokes method, do not detect VISA strains. The Centers for Disease Control and Prevention and other groups have issued recommendations regarding appropriate infection control procedures for patients infected with these strains. Centers for Disease Control and Prevention 2001 /pmc/articles/PMC2631729/ /pubmed/11294734 Text en
spellingShingle Research Article
Tenover, F C
Biddle, J W
Lancaster, M V
Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
title Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
title_full Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
title_fullStr Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
title_full_unstemmed Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
title_short Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus.
title_sort increasing resistance to vancomycin and other glycopeptides in staphylococcus aureus.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631729/
https://www.ncbi.nlm.nih.gov/pubmed/11294734
work_keys_str_mv AT tenoverfc increasingresistancetovancomycinandotherglycopeptidesinstaphylococcusaureus
AT biddlejw increasingresistancetovancomycinandotherglycopeptidesinstaphylococcusaureus
AT lancastermv increasingresistancetovancomycinandotherglycopeptidesinstaphylococcusaureus