Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.

Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian c...

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Autores principales: Vela Coral, M C, Fonseca, N, Castañeda, E, Di Fabio, J L, Hollingshead, S K, Briles, D E
Formato: Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631885/
https://www.ncbi.nlm.nih.gov/pubmed/11747695
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author Vela Coral, M C
Fonseca, N
Castañeda, E
Di Fabio, J L
Hollingshead, S K
Briles, D E
author_facet Vela Coral, M C
Fonseca, N
Castañeda, E
Di Fabio, J L
Hollingshead, S K
Briles, D E
author_sort Vela Coral, M C
collection PubMed
description Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective.
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spelling pubmed-26318852009-05-20 Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children. Vela Coral, M C Fonseca, N Castañeda, E Di Fabio, J L Hollingshead, S K Briles, D E Emerg Infect Dis Research Article Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective. Centers for Disease Control and Prevention 2001 /pmc/articles/PMC2631885/ /pubmed/11747695 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Article
Vela Coral, M C
Fonseca, N
Castañeda, E
Di Fabio, J L
Hollingshead, S K
Briles, D E
Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
title Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
title_full Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
title_fullStr Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
title_full_unstemmed Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
title_short Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
title_sort pneumococcal surface protein a of invasive streptococcus pneumoniae isolates from colombian children.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631885/
https://www.ncbi.nlm.nih.gov/pubmed/11747695
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